Treatment of Vaginal Trichomoniasis with Aminitrozole and Trichomycin Given Orally

Exploring new structural features of the 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases

“…1,3-thiazole and their hydrogenated analogues are important molecular subunits in diverse classes of biologically active molecules and thus can be found in several drugs approved for clinical use. Not surprisingly, this moiety has been extensively studied and both natural and synthetic thiazole derivatives are in therapeutic use or have shown potential therapeutic application toward several pathologies and targets such as bacteria 1,2 , tumours [3][4][5][6] , HIV-1 protease and reverse transcriptase [7][8][9][10][11][12] , fungi [13][14][15] , neurodegeneration and related pathologies 12,16,17 , and protozoal infections 18 . Recently, we reported on benzenesulphonamide dihydrothiazole derivatives as inhibitors of human carbonic anhydrase (hCA) isozymes I, II, IX, and XII19.…”