Treatment of vaginal agglutination associated with chronic graft-versus-host disease

Female Long-Term Survivors After Allogeneic Hematopoietic Stem Cell Transplantation: Evaluation and Management

“…Dense sclerotic changes pull the vaginal walls together narrowing and shortening the vaginal canal. Complete vaginal stenosis prevents cervical cytology testing and can lead to hematocolpos/hematometra in premenopausal women or menopausal women on cyclic hormone replacement 1,8,11 . Vaginal fasciitis, very rare feature, is associated with generalized sclerosing disease 3 .…”

Clinical guidelines for gynecologic care after hematopoietic SCT. Report from the international consensus project on clinical practice in chronic GVHD

“…(5) Regular intercourse or use of dilators can prevent vaginal narrowing and stenosis 14 (CIIIa). Prevention of vaginal stenosis is important to facilitate cervical cytology screening.…”

Acquired gynatresia

“…However, acquired vaginal cicatrisation or stenosis is of infrequent occurrence. Vaginal stenosis is typically defined as an inability to insert two fingers on examination6 Cases of acquired vaginal cicatrisation or stenosis reported from developed world occur associated with chronic graft-versus-host reaction either after receiving a bone marrow transplantation,7 or as a part of Steven-Johnson syndrome4 or after toxic epidermal necrolysis8 but more commonly after radiation therapy. Vaginal stenosis has also been reported after retention of a foreign body in the vagina 9.…”