Treatment of Urethral Syndrome with Triamcinolone Acetonide

Altman, Barry

doi:10.1016/s0022-5347(17)58919-3

Cited by 6 publications

(4 citation statements)

References 10 publications

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“…In a Swedish randomized study from 1972, urethral dilatation combined with instillation of chloromycetin-hydrocortisone (very low potency corticosteroid US class VII, Europe class I) was shown to relieve or remove symptoms in 44 % of women with symptoms of cysto-urethritis without concurrent findings of urinary tract infection [28]. In 1976 an American study presented a very good response in 54 women treated with sub-mucosal injections of the corticosteroid triamcinolone acetonide (moderate potency corticosteroid US class III, Europe class II) around the paraurethral glands [29]. In these studies no side effects were observed or mentioned.…”

Section: Discussionmentioning

confidence: 99%

Urethral instillations of clobetasol propionate and lidocaine: a promising treatment of urethral pain syndrome

Lindström¹,

Hellberg²,

Lindström³

2016

Clin. Exp. Obstet. Gynecol.

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To evaluate topical treatment with clobetasol propionate and lidocaine in women with urethral pain syndrome (UPS) in a retrospective pilot study. Materials and Methods: Urethral instillations of two ml clobetasol propionate cream and two ml lidocaine gel in 30 Caucasian women age 15-74 years with UPS between 1999 and 2006 were evaluated retrospectively. Instillations were given approximately once a week until the patient improved. Between one and 15 (median three) instillations were given. In substudy I a review was undertaken of the medical records to register the treatment effect at the end of the treatment (the last instillation) and any relapses six months thereafter. Substudy II was a follow-up at least five years after last instillation based on medical records and a written questionnaire. Results: Substudy I (n=30): By the end of the treatment 18 women had no symptoms and 12 were improved. Five patients had relapsed within six months. Substudy II (n=28): Twenty-eight women responded to the questionnaire. Four women remained with no symptoms, 18 remained improved, and six had the same symptoms as before treatment. Twenty women thought the treatment was very effective, five rather effective, and three women reported poor effect. Twenty-six women would ask for retreatment if a relapse occurred, two patients would not. No side effects, except transient pain, were reported. Conclusions: This retrospective study and longterm follow-up suggests that urethral instillation of clobetasol propionate and lidocaine is effective in treating women with UPS. Randomized control studies are warranted.

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Section: Discussionmentioning

confidence: 99%

Urethral instillations of clobetasol propionate and lidocaine: a promising treatment of urethral pain syndrome

Lindström¹,

Hellberg²,

Lindström³

2016

Clin. Exp. Obstet. Gynecol.

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“…However, lower urinary tract symptoms are also common in females [1,2,6,15,19]. The idea that outlet obstruction in women may cause frequency and urgency has long been accepted.…”

Section: Discussionmentioning

confidence: 99%

“…In the literature, pollakisuria, urgent straining and dysuria with the lack of objective urological findings, is known as urethral syndrome [1,4,6,8,15]. This myriad of symptoms may also be coined urgency/frequency syndrome, psychosomatic cystitis or spastic bladder reaction [15,19].…”

Section: Introductionmentioning

confidence: 99%

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Bladder Outlet Obstruction in Women: Difficulties in the Diagnosis

Klijer¹,

Bar²,

Białek³

2004

Urol Int

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Objective: To identify the difficulties in diagnosing bladder outlet obstruction in women. Material and Methods: 53 women with a mean age of 37.2 (range 16–70) with chronic lower urinary tract symptoms and no neurogenic or organic diseases were examined. The prevalent symptoms were frequency (96%), urgency (92%) and nocturia (75%), and the mean duration of symptoms was 3.8 years. After pressure-flow studies and voiding cystourethrography were conducted, patients either underwent bladder neck or urethral incisions based on their diagnosis. These patients were subsequently subjected to follow-up uroflow studies. Results: Abnormal uroflow curves were observed in 19 of 53 women. In 10 of them (52.6%), bladder outlet obstruction based on pressure-flow results was confirmed. Voiding cystourethrography results from these 19 women confirmed that 17 patients had bladder neck obstruction, while the remaining 2 had urethral obstruction. 16 of 19 were treated endoscopically, with 14 patients undergoing bladder neck incisions through the 5- and 7-o’clock positions and 2 patients having a distal urethral incision through the 12-o’clock position. In all of these 16 cases, there were both a statistical increase in the maximum flow rate (Q_max) as well as an improvement in the flow curves. Symptomatic improvement was observed in 12 of the 16 women subjected to surgical intervention. Conclusion: Bladder outlet obstruction exists in women with lower urinary tract symptoms. Pressure-flow studies and voiding cystourethrography are reliable modalities for confirming bladder outlet obstruction. Bladder outlet obstruction can be functionally or structurally caused.

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Die postcoitale „Urethritis“ der Frau

Bandhauer

1985

Verhandlungsbericht Der Deutschen Gesellschaft Für Urologie

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Treatment of Urethral Syndrome with Triamcinolone Acetonide

Abstract: A new method for the treatment of the urethral syndrome is presented. Therapy involves the submucosal injection of triamcinolone acetonide around Skene's glands to decrease inflammation and scarring. It is a simple office procedure, while all other therapeutic modalities are surgical.

Cited by 6 publications

References 10 publications

Urethral instillations of clobetasol propionate and lidocaine: a promising treatment of urethral pain syndrome

Urethral instillations of clobetasol propionate and lidocaine: a promising treatment of urethral pain syndrome

Bladder Outlet Obstruction in Women: Difficulties in the Diagnosis

Die postcoitale „Urethritis“ der Frau

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