Treatment of unresolved lower back pain with platelet-rich plasma injections

Darrow, Marc; Shaw, Brent; Nicholas, Schmidt; Boeger, Gabrielle

doi:10.1080/2331205x.2019.1581449

Cited by 4 publications

(6 citation statements)

References 34 publications

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“…One RTC study was still in the peer-review process at the time of analysis and was included as a personal communication to the author [73]. Additionally, the case series involved a total of 1759 patients, with studies focusing on intradiscal (160 patients) [34,56,[79][80][81][82][83], epidural (810 patients) [64,[84][85][86][87][88], facet injection (109 patients) [89][90][91], and lumbar muscles (171 patients) [61,92] or simultaneous application in multiple targets (509 patients) [10,[93][94][95][96][97][98][99][100]. The RCTs compared the effect of PRP with saline, steroids, contrast agent, hyaluronic acid, or ozone.…”

Section: Resultsmentioning

confidence: 99%

“…In the case series group, a total of 27 articles were found. Table 5 presents 18 papers focusing on specific targets, including the disc (n = 7) [34,56,[79][80][81][82][83], epidural space (n = 6) [64,[84][85][86][87][88], facet joint (n = 3) [89][90][91], and paravertebral muscle (n = 2) [61,92]. On the other hand, Table 6 includes nine papers that explored multitarget applications, involving the disc, facet, epidural space, and/or muscles simultaneously [10,[93][94][95][96][97][98][99][100].…”

Section: Resultsmentioning

confidence: 99%

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Systematic Review of Platelet-Rich Plasma for Low Back Pain

Machado,

Soares,

Vianna de Abreu

et al. 2023

Biomedicines

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Background: Low back pain (LBP) has a high economic burden and is strongly related to the degenerative process of the spine, especially in the intervertebral disc and of the facet joints. Numerous treatment modalities have been proposed for the management of LBP, and the use of platelet-rich plasma (PRP) has emerged as an innovative therapeutic option for degenerative disease of the spine. The present study aims to evaluate the efficacy of PRP injections in managing low back pain. Methods: We conducted a systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations, a registered at PROSPERO Systematic Reviews Platform, under number CRD42021268491. The PubMed, Web of Science, and Scopus databases were searched to identify relevant articles, along with hand searching to identify gray literature articles, with no language restrictions. Randomized clinical trials (RCTs), nonrandomized trials (NRTs), and case series (CSs) with more than 10 patients were considered eligible. The quality assessment and the risk of bias of the randomized clinical trials were evaluated using the RoB II tool. An evaluation of the description of the preparation methods was performed using an adapted version of the MIBO checklist. Results: An electronic database search resulted in 2324 articles, and after the exclusion of noneligible articles, 13 RCTs and 27 NRTs or CSs were analyzed. Of the 13 RCTs, 11 found favorable results in comparison to the control group in pain and disability, one showed no superiority to the control group, and one was discontinued because of the lack of therapeutic effect at eight-week evaluation. Description of the PRP preparation techniques were found in almost all papers. The overall risk of bias was considered high in 2 papers and low in 11. An adapted MIBO checklist showed a 72.7% compliance rate in the selected areas. Conclusions: In this systematic review, we analyzed articles from English, Spanish and Russian language, from large databases and grey literature. PRP was in general an effective and safe treatment for degenerative LPB. Positive results were found in almost studies, a small number of adverse events were related, the risk of bias of the RCTs was low. Based on the evaluation of the included studies, we graded as level II the quality of the evidence supporting the use of PRP in LBP. Large-scale, multicenter RCTs are still needed to confirm these findings.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Systematic Review of Platelet-Rich Plasma for Low Back Pain

Machado,

Soares,

Vianna de Abreu

et al. 2023

Biomedicines

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“…Although an extensive review of the literature has uncovered no reports of an ultrasound-guided PRP injection for treating specifically SSL and/or ISL pathology, Darrow et al [3] showed the benefits of injecting PRP into the back in 1, 2, or 3 injections. However, these injections were not image-guided and were instead performed at patient-reported areas of tenderness [1].…”

Section: Discussionmentioning

confidence: 99%

Successful Treatment of Supraspinous and Interspinous Ligament Injury With Ultrasound-Guided Platelet-Rich Plasma Injection: Case Series

Creighton

Sanguino

Cheng

et al. 2021

HSS Journal®: The Musculoskeletal Journal of Hospital for Speci

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“…Darrow et al [34] съобщават резултати от проспективно проучване, включващо 67 пациенти с хронична, "неспецифична" болка в кръста, която не е повлияна от стандартно лечение (включващо аналгетици и ФТ). Тези пациенти получават една или две (в разстояние от средно 24 дни) инжекции с ОТП в областта на интраспинозните лигаменти, тораколумбалната фасция и паравертебралната лумбална мускулатура.…”

Section: Prp Lbpunclassified

“…Darrow et al [34] reported results of a prospective study involving 67 patients with chronic, "non-specific" lumbar pain persistent after standard treatment (including analgesics and physiotherapy). These patients received one or two (at an interval of 24 days on average) injections with a PRP in the area of interspinous ligaments, the thoracolumbar fascia, and paravertebral lumbar musculature.…”

Section: Prp Lbpmentioning

confidence: 99%

Platelet rich plasma application in chronic low back pain – clinical and anatomical rationale and review of the literature

Todorov

Mekenjan

Popova

et al. 2019

Revmatologiia (Bulgaria)

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Low back pain (LBP) is an extremely common symptom in populations of all ages with significant economic and social burden worldwide. As such it should be among the priorities for trying to find more efficient methods for prevention and treatment. Currently the exact cause for the complaints can be found in most of the cases following thorough clinical examination, adequate diagnostic tests and modern image diagnosis. Most often the complaints are cause by degenerative processes affecting certain structures in the lumbosacral area – the intervertebral discs, the tendons/entheses along the iliac crest, the sacroiliac and lumbar facet joints. Platelet rich plasma (PRP) is a widely used therapeutic method aimed at recovering (both anatomical and functional) degenerative or traumatic damaged collagen tissues by injecting/applying autologous blood concentrate, rich in growth factors and other biologically active molecules. PRP demonstrates huge potential in stimulating cell proliferation and metabolic activity in vitro. Trials with animals show/prove the full recovery of the structural changes and the matrix integrity of the damaged tissue. In recent years some prospective clinical studies and published case series report that PRP could be a safe and efficient therapy for patients with chronic low back pain that do not yield to traditional/standard treatment options. Data though limited/scarce for the time being includes/covers the most common cause for this complaint, namely pathology of the intervertebral discs, facet and sacroiliac joints, as well as paraspinal soft tissues. The possibility for precise intralesional application of this regeneration autologous product in the damaged tissue gives it a huge advantage over the common algorithms currently used in the clinical practice to treat patients with such complaints. Future bigger studies including image methods to evaluate the structural recovery of the degenerative changed tissue responsible/blamed for the pain and functional deficit would bring light to the place PRP therapy should take in the treatment of low back pain.

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Treatment of unresolved lower back pain with platelet-rich plasma injections

Cited by 4 publications

References 34 publications

Systematic Review of Platelet-Rich Plasma for Low Back Pain

Systematic Review of Platelet-Rich Plasma for Low Back Pain

Successful Treatment of Supraspinous and Interspinous Ligament Injury With Ultrasound-Guided Platelet-Rich Plasma Injection: Case Series

Platelet rich plasma application in chronic low back pain – clinical and anatomical rationale and review of the literature

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