Treatment of Unresectable and Metastatic Hepatoblastoma: A Pediatric Oncology Group Phase II Study

Katzenstein, Howard M.; London, Wendy B.; Douglass, Edwin C.; Reynolds, Marleta; Plaschkes, J.; Finegold, Milton J.; Bowman, Laura C.

doi:10.1200/jco.2002.07.400

Cited by 95 publications

(70 citation statements)

References 22 publications

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“…The 1 child who died had unfavorable small cell undifferentiated histology and may have done equally poorly with transplantation. Our results compare favorably with the 79% event-free survival reported for COG stage III and IV tumors that are completely resected 17 and 82% overall survival for patients undergoing primary liver transplant for POST-TEXT III and IV tumors. 18 Liver transplantation plays an essential role in the management algorithm of children with large and multifocal hepatoblastoma.…”

Section: Discussionsupporting

confidence: 83%

Successful nontransplant resection of POST‐TEXT III and IV hepatoblastoma

Lautz

Ben-Ami

Tantemsapya

et al. 2010

Cancer

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Excellent survival (93%) was obtained with aggressive resection in children with POST-TEXT III and IV hepatoblastoma meeting criteria for transplant referral. The 1 death occurred in a patient with unfavorable small cell histology. These children should be managed at institutions experienced in both advanced pediatric hepatobiliary surgery and transplantation. Operative exploration was frequently required to ultimately determine which tumors can be resected and which require transplantation.

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Section: Discussionsupporting

confidence: 83%

Successful nontransplant resection of POST‐TEXT III and IV hepatoblastoma

Lautz

Ben-Ami

Tantemsapya

et al. 2010

Cancer

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“…There is no evidence at the moment supporting different therapeutic strategies to treat clinical and histological subtypes of pediatric hepatocellular carcinoma. The fibrolamellar variant does not appear to be clinically different (any better) from other subtypes of hepatocellular carcinoma 42 but, if resectable, is associated with a better 5-year survival (B55%) probably because of the absence of underlying liver disease in these patients. 43 One of the challenges to study the biology of pediatric hepatocellular carcinoma, has been the limited numbers of cases and the lack of banked Pediatric liver tumors classification specimens, as currently there are no therapeutic protocols or on-going pediatric clinical trials because of their rarity, highlighting the importance of collaborative and systematic efforts to collect and study these tumors, as well as integrating clinical, pathological, and biological data.…”

Section: Hepatocellular Carcinomamentioning

confidence: 99%

Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium

Alaggio²,

et al. 2014

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Liver tumors are rare in children, and their diagnoses may be challenging particularly because of the lack of a current consensus classification system. Systematic central histopathological review of these tumors performed as part of the pediatric collaborative therapeutic protocols has allowed the identification of histologic subtypes with distinct clinical associations. As a result, histopathology has been incorporated within the Children's Oncology Group (COG) protocols, and only in the United States, as a risk-stratification parameter and for patient management. Therefore, the COG Liver Tumor Committee sponsored an International Pathology Symposium in March 2011 to discuss the histopathology and classification of pediatric liver tumors, and hepatoblastoma in particular, and work towards an International Pediatric Liver Tumors Consensus Classification that would be required for international collaborative projects. Twenty-two pathologists and experts in pediatric liver tumors, including those serving as central reviewers for the COG, European Socié té Internationale d'Oncologie Pé diatrique, Gesellschaft fü r Pä diatrische Onkologie und Hä matologie, and Japanese Study Group for Pediatric Liver Tumors protocols, as well as pediatric oncologists and surgeons specialized in this field, reviewed more than 50 pediatric liver tumor cases and discussed classic and newly reported entities, as well as criteria for their classification. This symposium represented the first collaborative step to develop a classification that may lead to a common treatment-stratification system incorporating tumor histopathology. A standardized, clinically meaningful classification will also be necessary to allow the integration of new biological parameters and to move towards clinical algorithms based on patient characteristics and tumor genetics, which should improve future patient management and outcome.

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“…The combination of cisplatin-based chemotherapy and surgery has improved survival in patients with unresectable HB by increasing the number of patients whose tumors can be resected. Patients whose tumor may not be resectable even after neoadjuvant chemotherapy should be referred to a liver transplant center [44][45][46][47][48] .…”

Section: Fernandez-pineda I Et Al Liver Tumors In Infantsmentioning

confidence: 99%

Differential diagnosis and management of liver tumors in infants

Fernández-Pineda

Cabello-Laureano

2014

WJH

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During the first year of life, most of the liver neoplasms are benign in origin, but some of these histologically benign lesions may be challenging in their management. Although most hepatic hemangiomas can be safely observed until involution is documented, some patients will need treatment due to progressive hepatomegaly, hypothyroidism and/or cardiac failure. Large mesenchymal hamartomas may require extensive hepatic resection and an appropriate surgical plan is critical to obtain good results. For malignant neoplasms such as hepatoblastoma, complete surgical resection is the mainstay of curative therapy. The decision about whether to perform an upfront or delayed resection of a primary liver malignant tumor is based on many considerations, including the ease of resection, surgical expertise, tumor histology and stage, and the likely chemosensitivity of the tumor. This article reviews the initial management of the more common hepatic tumors of infancy, focusing on the differential diagnosis and treatment options.

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Treatment of Unresectable and Metastatic Hepatoblastoma: A Pediatric Oncology Group Phase II Study

Cited by 95 publications

References 22 publications

Successful nontransplant resection of POST‐TEXT III and IV hepatoblastoma

Successful nontransplant resection of POST‐TEXT III and IV hepatoblastoma

Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium

Differential diagnosis and management of liver tumors in infants

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