Treatment of Uncomplicated Gonorrhoea with a Single Dose of Amoxycillin

Double-blind trial of amoxycillin and ampicillin plus probenecid in the treatment of gonorrhoea in men.

“…These results are comparable to some obtained from areas with a much lower incidence of less sensitive strains. Alergant (1973) reported a cure rate of 94 2%o with amoxycillin 1 g plus probenecid 1 g in Liverpool; Willcox (1974), in London, obtained a cure rate of 98 8% using amoxycillin 3 g in two oral doses five hours apart; Karney et al (1974) had a cure rate of 9507o with amoxycillin 3 g and of 98% with ampicillin 3 5 g plus probenecid 1 g in Seattle; Deal et al (1974), in Florida, reported a 97% cure rate with amoxycillin 3 g; Gurwith et al (1974) using amoxycillin 3 g and 2 g plus probenecid 0 5 g obtained cure rates of 95-4% and 89 5% respectively in Manitoba; Roberts (1974) obtained rates of 84% and 950o using amoxycillin 1 g and 3 g respectively in Tennessee; and Wolk (1974), in California, claimed a cure rate of 94% in men using amoxycillin 3 g. Lassus et al (1975), in Helsinki, had a cure rate of 1007o with amoxycillin 3 g if the two possible reinfections are excluded. In London, Price and Fluker (1975) using amoxycillin 3 g obtained a cure rate of 997o in men and 95% in women assessed at the first follow-up three days later.…”