Treatment of Umbilical Granuloma in Infants With Topical Application of Common Salt: A Scoping Review

Common Salt versus Silver Nitrate for the Treatment of Umbilical Granuloma in Infants: An Open-label, Single-center, Pilot Randomized Controlled Trial

“…While the healing rates observed in this study were consistent with previous research findings,[ 4 ] it is noteworthy that there were no cases of iatrogenic periumbilical SN burns, which have been documented in the literature. [ 2 , 8 9 10 ] It is essential to highlight that in our study, SN application was performed by a pediatric surgeon in a clinical setting, whereas in the study by Daniels et al , it was administered by parents at home.…”

“…In determining the required sample size for this trial, it was assumed that the healing rate would range between 80% and 85% for CS and between 90% and 95% for SN treatment groups. [ 4 5 6 ] To meet this criterion, a sample size of 211 patients per group was deemed necessary to attain a statistical power exceeding 80%, while maintaining a two-sided type 1 error rate of 5%, using the formula:[ 7 ]…”

“…[ 3 ] The topical application of CS has garnered significant attention as an inexpensive and easily accessible homemade remedy, owing to its noted advantages in terms of both effectiveness and safety. [ 4 ] Salt has a desiccant effect, attributable to its high sodium ion concentration, which results in the removal of water from the intracellular compartment. This leads to contraction and necrosis of the moist granulation tissue without causing harm to the adjacent normal stratum corneum.…”