Treatment of Tumor‐Bearing Dogs With Actinomycin D

Hammer, Alan S.; Couto, C. Guillermo; Ayl, Rodney; Shank, Karen A.

doi:10.1111/j.1939-1676.1994.tb03224.x

Cited by 54 publications

(26 citation statements)

References 4 publications

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“…Other treatment modalities for perianal adenocarcinomas include estrogen therapy and systemic chemotherapy with actinomycin D. These treatment modalities are not frequently used due to side effects and limited effectiveness (Wilson and Hayes, 1979;Liska, 1980;Hammer et al, 1994;Thomas and Fox, 1998). Hyperthermia was tested in one study as an alternative treatment for perianal tumors.…”

Section: Side Effectsmentioning

confidence: 98%

Electrochemotherapy is highly effective for the treatment of canine perianal hepatoid adenoma and epithelioma

Tozon¹,

Kodre²,

Juntes³

et al. 2010

Acta vet. (Beogr.)

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Perianal tumors are common in older male dogs. The usefulness of electrochemotherapy in veterinary oncology has already been demonstrated by clinical studies on different malignancies in companion animals. In a prospective non-randomized study, we evaluated the effectiveness of electrochemotherapy in 5 male dogs with 26 perianal adenocarcinomas and 16 male dogs with 40 benign tumors. After premedication and under general anesthesia, the dogs were treated with intratumoral administration of a chemotherapeutic drug (cisplatin or bleomycin) and exposure of tumors to electric pulses, delivered by two different electroporation protocols (Protocol 1 or Protocol 2). At the end of the observation time (median 14 months), an objective response (OR) was obtained in 62/66 tumors (94%) with 87.9% complete responses (CR). No statistically significant difference in OR rate was observed based on histological type (p = 0.110), previous castration (p = 0.088), chemotherapeutic drug used (p = 0.657), and electroporation protocol (p = 0.337). Tumor size at the beginning of the treatment was the only parameter that influenced the treatment outcome (p = 0.04). No major local or general side-effects were noted. We can conclude that electrochemotherapy is an easy, highly effective, safe and cost-effective local approach for the treatment of primary perianal tumors of dogs, especially hepatoid adenoma and epithelioma

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Section: Side Effectsmentioning

confidence: 98%

Electrochemotherapy is highly effective for the treatment of canine perianal hepatoid adenoma and epithelioma

Tozon¹,

Kodre²,

Juntes³

et al. 2010

Acta vet. (Beogr.)

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“…Multiple treatment modalities have been utilized in the management of ASAGAC, including surgery, radiation therapy, chemotherapy, electrochemotherapy and various combinations thereof . Currently, there is no widely accepted standard of care for canine ASAGAC, other than to recommend surgical resection of the primary tumour and to consider adjuvant therapy.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of adjuvant carboplatin chemotherapy in the management of surgically excised anal sac apocrine gland adenocarcinoma in dogs

Wouda

Borrego

Keuler

et al. 2013

Vet Comparative Oncology

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There is no widely accepted standard of care for canine anal sac apocrine gland adenocarcinoma (ASAGAC). Surgery alone is inadequate in many cases, but the benefit of adjuvant chemotherapy is not well established. The primary objective of this retrospective study was to evaluate the role of carboplatin chemotherapy in the post-operative management of ASAGAC. Seventy-four dogs with naturally occurring ASAGAC underwent surgery. Forty-four dogs received adjuvant carboplatin and 30 did not. Median overall survival (OS) was 703 days. Median time to progression (TTP) was 384 days. Only primary tumour size and lymph node metastasis at diagnosis significantly impacted the outcome. Differences in OS and TTP, between the dogs that received adjuvant carboplatin and those that did not, failed to reach statistical significance. Treatment of progressive disease, whilst not limited to chemotherapy, significantly prolonged the survival. This study shows that adjuvant carboplatin chemotherapy is well tolerated and may have a role in the management of dogs with ASAGAC.

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“…2nd remission durations using rescue protocols are also relatively short, generally 1-5 months. [15][16][17][18] Although high response rates and prolonged remission durations are documented in humans with lymphoma treated with the MOPP chemotherapy, few reports describe the use of the MOPP protocol in dogs with lymphoma (Rosenberg and Matus, personal communication). The objectives of this retrospective study were to evaluate the toxicity and relative efficacy of the MOPP protocol when used as a rescue therapy in dogs with lymphoma that had developed resistance or failed to respond to previously administered chemotherapy.…”

mentioning

confidence: 99%

MOPP Chemotherapy for Treatment of Resistant Lymphoma in Dogs: A Retrospective Study of 117 Cases (1989–2000)

Rassnick

Mauldin

Al-Sarraf

et al. 2002

Veterinary Internal Medicne

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The purpose of this retrospective study was to evaluate the efficacy and toxicity of the MOPP chemotherapy protocol (mechlorethamine, vincristine, procarbazine, and prednisone) as a rescue regimen in dogs with lymphoma. One hundred seventeen dogs that had resistance to previously administered chemotherapy were evaluated. Before treatment with MOPP, all dogs received a median of 6 chemotherapy drugs for a median duration of 213 days. Thirty-one percent (36 of 117) had a complete response (CR) to MOPP for a median of 63 days, and 34% (40 of 117) had a partial response (PR) for a median of 47 days. Sixteen percent (19 of 117) had stable disease (SD) for a median of 33 days. Predictors for response to MOPP were not identified. Gastrointestinal (GI) toxicity occurred in 28% (33 of 117) of the dogs, and 13% (15 dogs) required hospitalization. Five dogs developed septicemia, and 2 died as a result. MOPP was an effective treatment for dogs with resistant lymphoma and was well tolerated by the majority of affected dogs.Key words: Canine; Lymphosarcoma; Rescue. The MOPP chemotherapy protocol (mechlorethamine, a vincristine, b procarbazine, c and prednisone) was designed by DeVita et al in 1964 and was the 1st successful combined drug regimen for the treatment of humans with Hodgkin's and non-Hodgkin's lymphoma.1,2 Up to 85% of humans with advanced lymphoma and no previous chemotherapy exposure will achieve a complete remission when treated with MOPP. Approximately 70% of these remissions are durable, and disease-free long-term survivors have a high chance of being cured.2,3 Currently, several alternative chemotherapeutic regimens with superior results and often fewer toxicities exist for use in humans. 4,5 However, the development of MOPP was a milestone in oncology, demonstrating that advanced disease could be controlled.Durable 1st remissions are achievable in Ͼ80% of previously untreated dogs with lymphoma by combination chemotherapy protocols. 1st remissions last 4-14 months. [6][7][8][9][10][11][12][13][14] Rescue therapy attempts to establish remission in an animal with lymphoma that has failed 1st-line treatments or to reestablish remission in an animal that has relapsed after previous treatment. Unfortunately, durable remissions with rescue therapy are uncommon in dogs. Most rescue protocols Veterinary Medicine, Cornell University, Ithaca, NY 14853; e-mail: kmr32@cornell.edu. Submitted December 10, 2001; Revised February 19, 2002; Accepted March 19, 2002. Copyright ᭧ 2002 result in 30-50% response rates. 2nd remission durations using rescue protocols are also relatively short, generally 1-5 months. 15-18Although high response rates and prolonged remission durations are documented in humans with lymphoma treated with the MOPP chemotherapy, few reports describe the use of the MOPP protocol in dogs with lymphoma (Rosenberg and Matus, personal communication). The objectives of this retrospective study were to evaluate the toxicity and relative efficacy of the MOPP protocol when used as a rescue therapy in dogs wi...

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Treatment of Tumor‐Bearing Dogs With Actinomycin D

Cited by 54 publications

References 4 publications

Electrochemotherapy is highly effective for the treatment of canine perianal hepatoid adenoma and epithelioma

Electrochemotherapy is highly effective for the treatment of canine perianal hepatoid adenoma and epithelioma

Evaluation of adjuvant carboplatin chemotherapy in the management of surgically excised anal sac apocrine gland adenocarcinoma in dogs

MOPP Chemotherapy for Treatment of Resistant Lymphoma in Dogs: A Retrospective Study of 117 Cases (1989–2000)

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