Treatment of Trichuriasis with Dithiazanine

Treatment of Trichuriasis with Dithiazanine in a Hospital for Mental Defectives

“…Swartzwelder et al (1957) have demonstrated that satisfactory results are to be obtained from treating human trichuriasis with dithiazanine, and in our preliminary report (Paine et al, 1959) we confirm these findings. Our controlled trial experiment and masstreatment programme have been designed to discover whether patients with positive trichuris egg counts can be finally cleared from the infestation, and whether a partially closed community, such as a hospital for mental defectives, can be freed from whipworm by the use of dithiazanine.…”

“…Since the publication of our preliminary report (Paine et al, 1959) on the treatment of six patients known to be infected with trichuriasis, it has been possible to plan a controlled trial experiment with dithiazanine and arrange a full-scale treatment programme of all whipworm carriers at Coldharbour Hospital.…”

Quaternary Ammonium Compounds in Medicinal Chemistry, II

“…Thus, it is extremely active against Strongyloides stercoralis, and in this respect is superior to many other anthelmintics (Brumpt and Ho-Thi-Sang, 1959 ;Lloyd, 1959). It is also active in the treatment of trichuriasis in man (Brumpt and HoThi-Sang, 1959 ;Paine, Lower and Cooper, 1959), and against Trichuris vulpis, the canine whipworm (Bueding, Kmetec, Swartzwelder, Abadie and Saz, 1961). Dithiazanine is highly effective against pinworm infections, but since its use is associated with a much higher incidence of gastrointestinal side-effects than is therapy with piperazine, the latter agent is considered preferable (Brown, 1960).…”