Treatment of Tobacco Amblyopia With Vasodilators

Clinical Aspects of Acetylcholine--I

“…Hartmann (1933) gave repeated intramuscular injections of 0.1 gramme in various arterial lesions with visual defects, obtaining favourable results; and Orr and Young (1935) by subconjunctival injections obtained a rapid return of vision in a case of embolism of the central artery of the retina, -and the embolus was observed to move towards the periphery. Duggan (1937a) treated two cases of acute retrobulbar neuritis with repeated doses of 0.1 gramme intramuscularly, and considered that the vision returned more rapidly than in eight similar cases treated with amyl nitrite or intravenous injections of sodium nitrite. Hartmann (1933) believed acetylcholine to be the best therapeutic agent in tobacco amblyopia when given by the intramuscular route, Orr (1936) reported good results from the same method, and Cragg (1936) considered that it hastened recovery, but Duggan (1937b), who used intravenous injections, found it of doubtful value.…”

“…Duggan (1937a) treated two cases of acute retrobulbar neuritis with repeated doses of 0.1 gramme intramuscularly, and considered that the vision returned more rapidly than in eight similar cases treated with amyl nitrite or intravenous injections of sodium nitrite. Hartmann (1933) believed acetylcholine to be the best therapeutic agent in tobacco amblyopia when given by the intramuscular route, Orr (1936) reported good results from the same method, and Cragg (1936) considered that it hastened recovery, but Duggan (1937b), who used intravenous injections, found it of doubtful value.…”