“…Irwin, Van Vactor and Norris (27) feel that the length of time required to bring the patient to a euthyroid state varies directly with the size of the goiter. Bartels (28, 29) and Kendrick, Balls and Rose (30) are of the opinion that with antithyroid compounds it takes longer to control the nodular than the diffusely hyperplastic goiter. On the other hand, the present data, and our own experience with antithyroid compounds (31, 32, 33) are in accord with the conclusion of Hallman and Bondy (34), who state that neither a longer period of time nor a larger dose of drug are necessary to control toxic nodular goiter as compared with toxic diffuse hyperplastic goiter.…”