Treatment of thrombosis in KD Patients using tissue plasminogen activator: a single center study

Chu, Yan-Qiu; Xu, Yu; Yu, Xin; Ma, Qingtian; Wang, Hong

doi:10.1186/s12969-022-00767-7

Cited by 4 publications

(3 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, Plat has been extensively studied for its therapeutic potential in treating thrombotic disorders like ischemic stroke and myocardial infraction. [84][85][86][87][88] Therefore, further research is required to clarify the exact role of Plat in osteoblast differentiation and bone formation and its potential as a therapeutic target for osteoporosis and other bone-related disorders.…”

Section: Discussionmentioning

confidence: 99%

“…These findings underscore the complex and context‐dependent roles of Plat and PAI‐1 in bone physiology and highlight the importance of investigating their regulation and interactions in osteoblast differentiation. Notably, Plat has been extensively studied for its therapeutic potential in treating thrombotic disorders like ischemic stroke and myocardial infraction 84–88 . Therefore, further research is required to clarify the exact role of Plat in osteoblast differentiation and bone formation and its potential as a therapeutic target for osteoporosis and other bone‐related disorders.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Mechanical induction of osteoanabolic Wnt1 promotes osteoblast differentiation via Plat

Ahmad,

Haffner‐Luntzer,

Schoppa

et al. 2024

The FASEB Journal

View full text Add to dashboard Cite

Physical activity‐induced mechanical stimuli play a crucial role in preserving bone mass and structure by promoting bone formation. While the Wnt pathway is pivotal for mediating the osteoblast response to loading, the exact mechanisms are not fully understood. Here, we found that mechanical stimulation induces osteoblastic Wnt1 expression, resulting in an upregulation of key osteogenic marker genes, including Runx2 and Sp7, while Wnt1 knockdown using siRNA prevented these effects. RNAseq analysis identified Plat as a major target through which Wnt1 exerts its osteogenic influence. This was corroborated by Plat depletion using siRNA, confirming its positive role in osteogenic differentiation. Moreover, we demonstrated that mechanical stimulation enhances Plat expression, which, in turn leads to increased expression of osteogenic markers like Runx2 and Sp7. Notably, Plat depletion by siRNA prevented this effect. We have established that Wnt1 regulates Plat expression by activating β‐Catenin. Silencing Wnt1 impairs mechanically induced β‐Catenin activation, subsequently reducing Plat expression. Furthermore, our findings showed that Wnt1 is essential for osteoblasts to respond to mechanical stimulation and induce Runx2 and Sp7 expression, in part through the Wnt1/β‐Catenin/Plat signaling pathway. Additionally, we observed significantly reduced Wnt1 and Plat expression in bones from ovariectomy (OVX)‐induced and age‐related osteoporotic mouse models compared with non‐OVX and young mice, respectively. Overall, our data suggested that Wnt1 and Plat play significant roles in mechanically induced osteogenesis. Their decreased expression in bones from OVX and aged mice highlights their potential involvement in post‐menopausal and age‐related osteoporosis, respectively.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Mechanical induction of osteoanabolic Wnt1 promotes osteoblast differentiation via Plat

Ahmad,

Haffner‐Luntzer,

Schoppa

et al. 2024

The FASEB Journal

View full text Add to dashboard Cite

show abstract

“…Several antithrombotic agents, including anticoagulants, antiplatelets, and brinolytics are recommended for the treatment of thrombotic events in pediatric patients. Currently, the primary choices remain with anticoagulants and antiplatelet therapies (22). Among these, the most extensively studied agents in the context of pediatric thrombosis are unfractionated heparin, low-molecular-weight heparin (LMWH), and warfarin.…”

Section: Discussionmentioning

confidence: 99%

Establishment of Iranian Pediatric Thrombosis Registry (IPTR) by Iranian Society of Thrombosis and Hemostasis (IRSTH): A Preliminary Report

Kamfar,

Alavi,

Eshghi

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Pediatric thromboembolism is a rare and heterogenous condition with increasing trend in children with underlying medical conditions specifically in hospitalized children. Due to the low rate of the thrombotic events in children, most current guidelines are extrapolated from adult studies despite several differences between adults and children. In this regard, the Iranian Society of Thrombosis and Hemostasis (IRSTH) developed the national registry of Iranian Pediatric Thrombosis Registry (IPTR) in 2022. The aims of the IPTR include (1) establishment of a software-based registration system for pediatrics with thrombotic events in academic centers all over the country, and (2) collaborate with international networks to share data and participate in clinical trials and/or observational cohort studies and propose research idea based upon existing data. Methods To establish the registry, several assembly meetings including pediatric hematologist/oncologists, executive committees, biostatisticians, and software designers were held. A web-based software according to the final database consisting of mandatory data including name of the referral centers, patients' demographic data, age at diagnosis, type (venous or arterial) and location of the thrombosis, risk factors, treatment plan and disease-related events, and optional database was set up. Results Over nine months since establishment of the IPTR, data of 69 patients (43 males and 26 females) were registered. Venous and arterial thrombosis were observed in 89.8% and 8.7% of the patients, respectively. The most common sites in venous system were abdominal (41.9%), followed by cerebral venous sinus (32.8%), upper (29.0%) and lower extremities (27.4%). All arterial events occurred in CNS in territory of the middle cerebral artery. The most frequent risk factors were catheters (20%), followed by malignancies (18.8%), surgery (17%), liver disease (15%) and hereditary thrombophilia (10%). Anticoagulant therapy was prescribed in 87.5% of cases. Low molecular weight heparin followed by rivaroxaban were the most common prescribed anticoagulants. Three out of 6 patients with thrombosis of MCA received antiplatelets (aspirin). Conclusion This preliminary report presented the initial data on pediatric thrombotic events following the establishment of the first Iranian pediatric thrombosis registry.

show abstract

Multiple drugs

2023

Reactions Weekly

View full text Add to dashboard Cite

Treatment of thrombosis in KD Patients using tissue plasminogen activator: a single center study

Cited by 4 publications

References 35 publications

Mechanical induction of osteoanabolic Wnt1 promotes osteoblast differentiation via Plat

Mechanical induction of osteoanabolic Wnt1 promotes osteoblast differentiation via Plat

Establishment of Iranian Pediatric Thrombosis Registry (IPTR) by Iranian Society of Thrombosis and Hemostasis (IRSTH): A Preliminary Report

Multiple drugs

Contact Info

Product

Resources

About