Treatment of the Phobic Obsessive- Compulsive Patient With Oxazepam, an Improved Benzodiazepine Compound

Orvin, George H.

doi:10.1016/s0033-3182(67)71943-x

Cited by 18 publications

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chlordiazepoxide was less effective than the new benzodiazepines in 61 % of the studies, equivalent in 31%, and more effective in 8%. [8][9][10][11][12][13][14][15][16][17][18][19][20] The variance in results emphasizes the difficulties in interpreting large numbers of comparative clinical trials. The differences between drugs may be real or illusory, and this very often depends on the size and nature of the study population and the relative dosages of each drug.…”

Section: Clinical Differencesmentioning

confidence: 99%

Is Chlordiazepoxide the Rational Choice Among Benzodiazepines?

1982

View full text Add to dashboard Cite

Diazepam is frequently the subject of review by various agencies and institutions charged with determining whether or not to substitute another, more economical drug--in most instances, chlordiazepoxide. A review of the comparative literature has shown that, on clinical and pharmacokinetic grounds, chlordiazepoxide is not the drug of choice for all clinical indications recommended for the benzodiazepines as a class, particularly for use as an antianxiety agent. There is evidence that the antianxiety effect of chlordiazepoxide is related to the appearance of its two active metabolites, which may explain the observed delay in its onset of action. When chlordiazepoxide's reduced clearance in the elderly and in patients with liver disease is considered along with its limited range of indications, substitution of diazepam with chlordiazepoxide is clearly not reasonable. Diazepam and lorazepam are preferred choices in acute anxiety because they are themselves active anxiolytics. Oxazepam is recommended in alcoholic cirrhotics because its plasma clearance does not seem to be significantly affected by liver disease. Diazepam is recommended for chronic anxiety because of the rapid onset of action of diazepam itself and the smooth transition to the nondrug state via its longer-acting active metabolite.

show abstract

Section: Clinical Differencesmentioning

confidence: 99%

Is Chlordiazepoxide the Rational Choice Among Benzodiazepines?

1982

View full text Add to dashboard Cite

show abstract

A Multicenter Investigation of Fixed-Dose Fluoxetine in the Treatment of Obsessive-compulsive Disorder

Tollefson¹

1994

Arch Gen Psychiatry

250

View full text Add to dashboard Cite

show abstract

Pharmacotherapy of Obsessive‐Compulsive Disorder

Jermain,

Crismon

1990

Pharmacotherapy

View full text Add to dashboard Cite

Obsessive‐compulsive disorder (OCD) is a potentially devastating illness, both to the patient and family members. Its etiology is unclear, but some evidence points toward dysfunction in an orbitofrontal striatal‐limbic neuronal loop. Although many agents have been used, clomipramine, a tricyclic antidepressant, appears to be the most promising therapy. Clomipramine was approved by the Food and Drug Administration and released for general use in early 1990 under the brand name Anafranil. Clomipramine's adverse effect profile is similar to that of currently marketed tricyclic antidepressants; however, it is associated with a higher frequency of seizures, estimated to be 0.7%. Although other serotonergic agents such as fluoxetine have shown promise in OCD, they have been studied only in a limited number of patients. Other agents, with the possible exception of monoamine oxidase inhibitors, either have resulted in inconsistent improvement or have been reported in an anecdotal fashion.

show abstract

Treatment of the Phobic Obsessive- Compulsive Patient With Oxazepam, an Improved Benzodiazepine Compound

Cited by 18 publications

References 3 publications

Is Chlordiazepoxide the Rational Choice Among Benzodiazepines?

Is Chlordiazepoxide the Rational Choice Among Benzodiazepines?

A Multicenter Investigation of Fixed-Dose Fluoxetine in the Treatment of Obsessive-compulsive Disorder

Pharmacotherapy of Obsessive‐Compulsive Disorder

Contact Info

Product

Resources

About