Treatment of systolic hypertension: spotlight on recent studies with angiotensin II antagonists

Volpe, Massimo

doi:10.1038/sj.jhh.1001781

Cited by 15 publications

(7 citation statements)

References 94 publications

(97 reference statements)

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“…In addition to altered content, collagen undulation, orientation, cross-linking, and interactions with other ECM elements are fundamental to defining arterial wall stiffness and hypertension. Ang II induces hypertension by increasing collagen and decreasing elastin content, creating an imbalance between elastic and rigid ECM components in the vascular wall [184]. The stiffness of elastin and collagen fibers can be increased through additional crosslinking by AGEs.…”

Section: Ecm Protein Synthesis and Assembly In Aortic And Venous Dmentioning

confidence: 99%

Vascular wall extracellular matrix proteins and vascular diseases

Shi

2014

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

289

239

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Extracellular matrix proteins form the basic structure of blood vessels. Along with providing basic structural support to blood vessels, matrix proteins interact with different sets of vascular cells via cell surface integrin or non-integrin receptors. Such interactions induce vascular cell de novo synthesis of new matrix proteins during blood vessel development or remodeling. Under pathological conditions, vascular matrix proteins undergo proteolytic processing, yielding bioactive fragments to influence vascular wall matrix remodeling. Vascular cells also produce alternatively spliced variants that induce vascular cell production of different matrix proteins to interrupt matrix homeostasis, leading to increased blood vessel stiffness; vascular cell migration, proliferation, or death; or vascular wall leakage and rupture. Destruction of vascular matrix proteins leads to vascular cell or blood-borne leukocyte accumulation, proliferation, and neointima formation within the vascular wall; blood vessels prone to uncontrolled enlargement during blood flow diastole; tortuous vein development; and neovascularization from existing pathological tissue microvessels. Here we summarize discoveries related to blood vessel matrix proteins within the past decade from basic and clinical studies in humans and animals — from expression to cross-linking, assembly, and degradation under physiological and vascular pathological conditions, including atherosclerosis, aortic aneurysms, varicose veins, and hypertension.

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Section: Ecm Protein Synthesis and Assembly In Aortic And Venous Dmentioning

confidence: 99%

Vascular wall extracellular matrix proteins and vascular diseases

Shi

2014

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

289

239

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“…Angiotensin receptor blockers (ARBs) are a promising alternative for the treatment of SH, in part, at least because angiotensin II plays a prominent role in the development of arterial stiffness 17 . In patients with SH and left ventricular hypertrophy, losartan significantly reduced stroke compared with atenolol, despite similar reductions in BP 18 .…”

mentioning

confidence: 99%

Telmisartan Plus HCTZ vs. Amlodipine Plus HCTZ in Older Patients With Systolic Hypertension: Results From a Large Ambulatory Blood Pressure Monitoring Study

Neldam¹,

Edwards²

2006

American J Geri Cardiology

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Systolic hypertension often requires combination therapy. Few data exist comparing angiotensin receptor blocker plus diuretic therapy with other combinations in older patients. In a prospective, randomized, open-label, blinded-end point trial, patients (> or =60 years of age) with predominantly systolic hypertension received telmisartan 40-80 mg or amlodipine 5-10 mg for 8 weeks, before the addition of hydrochlorothiazide (HCTZ) 12.5 mg for a further 6 weeks. Twenty-four-hour ambulatory blood pressure monitoring showed that telmisartan plus HCTZ (n=448) and amlodipine plus HCTZ (n=424) changed systolic blood pressure for the last 6 hours of the dosing interval by -18.3 and -17.4 mm Hg, respectively (p=0.2520). Over the 24-hour period, telmisartan plus HCTZ was superior (-19.3 and -17.2 mm Hg, respectively; p=0.001) and provided higher systolic control rates (65.9% and 58.3%, respectively; p=0.0175). Adverse events (41.2% and 53.7%, respectively) and discontinuations (5.0% and 11.3%, respectively) were lower (p<0.0001) with telmisartan than with amlodipine, mainly due to peripheral edema (1.2% and 24.3%, respectively).

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“…Simple structural changes such as wall thickening can affect the stiffness and contractility of the vessel and may be linked to pathological remodeling . For example, the intima thickening is a risk factor for atherosclerosis .…”

Section: Introductionmentioning

confidence: 99%

High resolution imaging of the fibrous microstructure in bovine common carotid artery using optical polarization tractography

Azinfar

Ravanfar

Wang

et al. 2015

Journal of Biophotonics

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The biomechanical properties of artery are primarily determined by the fibrous structures in the vessel wall. Many vascular diseases are associated with alternations in the orientation and alignment of the fibrous structure in the arterial wall. Knowledge on the structural features of the artery wall is crucial to our understanding of the biology of vascular diseases and the development of novel therapies. Optical coherence tomography (OCT) and polarization-sensitive OCT have shown great promise in imaging blood vessels due to their high resolution, fast acquisition, good imaging depth, and large field of view. However, the feasibility of using OCT based methods for imaging fiber orientation and distribution in the arterial wall has not been investigated. Here we show that the optical polarization tractography (OPT), a technology developed from Jones matrix OCT, can reveal the fiber orientation and alignment in the bovine common carotid artery. The fiber orientation and alignment data obtained in OPT provided a robust contrast marker to clearly resolve the intima and media boundary of the carotid artery wall. Optical polarization tractography can visualize fiber orientation and alignment in carotid artery.

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Treatment of systolic hypertension: spotlight on recent studies with angiotensin II antagonists

Cited by 15 publications

References 94 publications

Vascular wall extracellular matrix proteins and vascular diseases

Vascular wall extracellular matrix proteins and vascular diseases

Telmisartan Plus HCTZ vs. Amlodipine Plus HCTZ in Older Patients With Systolic Hypertension: Results From a Large Ambulatory Blood Pressure Monitoring Study

High resolution imaging of the fibrous microstructure in bovine common carotid artery using optical polarization tractography

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