Treatment of superficial basal cell carcinoma with photodynamic therapy. Observational study in 22 patients with 5-aminolaevulinic acid and methyl aminolaevulinate

Alique-García, Sergio; Company-Quiroga, Jaime; Campos, Alberto Sánchez; Núñez, Almudena Hernández; Borbujo, J.

doi:10.1016/j.pdpdt.2019.03.018

Cited by 6 publications

(4 citation statements)

References 2 publications

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“…Alique-García et al in a group of 22 patients diagnosed with sBCC receiving PDT showed that after one year, 93.75% of foci resolved after ALA-HCl (BF-200) and 50% after MAL-HCl. There were no differences in the aspect of tolerability, which was defined as good or regular [34].…”

Section: Discussionmentioning

confidence: 90%

Efficacy of photodynamic therapy using ALAHCl in gel with a lipid nanoemulsion and MALHCl in cream in superficial basal cell carcinoma

Szczepanik-Kułak,

Bartosińska,

Kowalczuk

et al. 2024

Ann Agric Environ Med.

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Introduction and Objective. Photodynamic therapy (PDT) is a therapeutic option for low-risk basal cell carcinoma (BCC). The aim of the study was to assess the efficacy of topical PDT in the treatment of superficial BCC (sBCC) using two different photosensitizers: aminolevulinic acid hydrochloride (ALA-HCl) in a gel formulation with a lipid nanoemulsion (ALA-HCl in gel) and ALA methyl ester hydrochloride (MAL-HCl) in a cream formulation (MAL-HCl in cream). Materials and Method. 21 patients were treated twice with a one week interval between treatments. The formulations were applied onto lesions: 10 patients were treated with MAL-HCl in cream, and 11 with ALA-HCl in gel. After three hours of incubation and removing the preparations, fluorescence was assessed. The skin areas were then irradiated with red light 630 ± 5 nm. Results. At the follow-up visit 12 weeks after the second treatment, complete clinical remission was found in 82% after ALA-HCl in gel and in 80% after MAL-HCl in cream. An excellent cosmetic result was found in 96% of patients after MAL-HCl in cream and in 100% after ALA-HCl in gel. Faster skin healing and less post-inflammatory hyperpigmentation during follow-up visits was observed after treatment with ALA-HCl in gel. Conclusions. Both formulations -ALA-HCl in gel and MAL-HCl in cream -were highly effective photosensitisers for PDT. The advantage of ALA-HCl in a gel formulation with a lipid nanoemulsion was faster skin healing, resulting in better cosmetic results.

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Section: Discussionmentioning

confidence: 90%

Efficacy of photodynamic therapy using ALAHCl in gel with a lipid nanoemulsion and MALHCl in cream in superficial basal cell carcinoma

Szczepanik-Kułak,

Bartosińska,

Kowalczuk

et al. 2024

Ann Agric Environ Med.

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“…PDT is presented as an alternative treatment for BCC tumors. PDT is regarded as highly appropriate treatment option for low‐risk tumors, such as Bowen's disease, 4 or sBCC 5 . The mainly advantages of PDT, when compared with topical treatments such as imiquimod or 5‐FU, include excellent compliance, short treatment duration (adherence), and better cosmetic results after treatment.…”

Section: Discussionmentioning

confidence: 99%

“…PDT is regarded as highly appropriate treatment option for low-risk tumors, such as Bowen's disease, 4 or sBCC. 5 The mainly advantages of PDT, when compared with topical treatments such as imiquimod or 5-FU, include excellent compliance, short treatment duration (adherence), and better cosmetic results after treatment. Regarding efficacy, PDT has been shown to present highly effective data for the treatment of actinic keratosis 6 and sBCC.…”

Section: Discussionmentioning

confidence: 99%

Treatment of superficial basal cell carcinoma with 7.8% 5‐aminolaevulinic acid nanoemulsion‐based gel ( BF ‐200 ALA ) and photodynamic therapy: Results in clinical practice in a tertiary hospital

Navarro‐Triviño

Ayén‐Rodríguez

Llamas‐Molina

et al. 2020

Dermatologic Therapy

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Photodynamic therapy (PDT) is an effective treatment option for the treatment of superficial basal cell carcinoma (sBCC). Recent publications have demonstrated that PDT with 7.8% 5‐aminolaevulinic acid nanoemulsion‐based gel (BF‐200 ALA‐PDT) is an effective and safe alternative for the treatment of sBCC). To investigate the efficacy and safety of 7.8% 5‐aminolaevulinic acid nanoemulsion‐based gel (BF‐200 ALA)‐PDT for the treatment of sBCC. A non‐controlled, open‐label single centre study was conducted. Patients received one PDT cycle with two PDT sessions one‐week apart. In case that clinical‐dermoscopy evaluation of treatment outcome revealed remaining lesions, a second PDT cycle was performed. The clinical results at the dermoscopy and fluorescence diagnosis level were histologically confirmed in all patients. Treatment response was evaluated 3, 6, and 12 months after last PDT session. A total of 31 patients (12 men and 19 women), with a median age of 63.74 years were included in this study. 3‐month after PDT‐session, 23/31 patients were complete responders (74.19%) after two BF‐200 ALA ‐PDT sessions. Esthetic outcome was considered good‐to‐excellent. 5 Aminolevulinic acid 7.8% nanoemulsion‐based gel (BF‐200 ALA) PDT is an effective therapy option for the treatment of sBCC. Complete clearance rates were higher in those patients who received only one PDT cycle. These results show a similar tendency as shown in other publications.

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“…cell carcinoma (Fernández-Guarino et al, 2014;Alique-García et al, 2019b). In addition, promising results have been obtained in recent years in the treatment of other tumors, inflammatory or infectious pathologies, as well as in cosmetic treatments (Gilaberte et al, 2006;Park et al, 2013).…”

Section: Case Studymentioning

confidence: 99%

Interactive visual clustering and classification based on dimensionality reduction mappings: A case study for analyzing patients with dermatologic conditions

Mohedano-Munoz

Alique-García

Rubio-Sánchez

et al. 2021

Expert Systems with Applications

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Treatment of superficial basal cell carcinoma with photodynamic therapy. Observational study in 22 patients with 5-aminolaevulinic acid and methyl aminolaevulinate

Cited by 6 publications

References 2 publications

Efficacy of photodynamic therapy using ALAHCl in gel with a lipid nanoemulsion and MALHCl in cream in superficial basal cell carcinoma

Efficacy of photodynamic therapy using ALAHCl in gel with a lipid nanoemulsion and MALHCl in cream in superficial basal cell carcinoma

Treatment of superficial basal cell carcinoma with 7.8% 5‐aminolaevulinic acid nanoemulsion‐based gel ( BF ‐200 ALA ) and photodynamic therapy: Results in clinical practice in a tertiary hospital

Interactive visual clustering and classification based on dimensionality reduction mappings: A case study for analyzing patients with dermatologic conditions

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