Treatment of squamous cell carcinoma of the lip using Foscan-mediated Photodynamic Therapy

Kübler, Alexander C.; Carpentier, J.-P.; Hopper, Colin; Leonard, Alan G.; Putnam, Graham

doi:10.1054/ijom.2001.0160

Cited by 95 publications

(74 citation statements)

References 23 publications

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“…It is pertinent to note that laser also have the precise ability to remove mutagenic clones from oral mucosa as they develop and thereby prevent development of cancer in situ [7]. However the current notion is that laser ablative techniques are suitable for dysplastic lesions of lip only as this technique does not distinguish between normal and cancerous tissue and there is no histological control over the margins of the tumor [3]. Thus not surprisingly scant medical literature exists on the cited subject.…”

Section: Discussionmentioning

confidence: 99%

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Nd:YAG laser therapy of carcinoma lip (stage I squamous cell carcinoma): a retrospective evaluation

Singh

Tiwari

Shukla

et al. 2009

Indian J Otolaryngol Head Neck Surg

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Objective To asses the effi cacy of Nd:YAG laser for stage I squamous cell carcinoma of the lip. To the authors' knowledge this is the fi rst reported study on this subject. Study designRetrospective study design involving treatment of 46 patients of either sex of stage I squamous cell carcinoma of lip over a 10-year period in a single tertiary care university teaching hospital with Nd:YAG laser.Methods Nd:YAG laser ablation of lesions in lip was carried out in all the patients on an OPD basis with prior consent. A regular follow-up was maintained for a period of 5 years. A negative biopsy at the end of one month and one year was considered a treated case. The tabulated data was analysed statistically by "Kaplan Meier" method and "Log Rank" test. Also cosmetic and functional results were assessed by any sign of fl ow away after fi lling the oral cavity with water and postoperative integrity of facial nerve in accordance with "House Brackmann" classifi cation.Results In this series of 46 patients, 35 patients were disease free at the end of 3 years and this number further declined to 29 at the end of 5 years with 4 deaths and 2 more patients lost to follow-up. The statistical evaluation by Kaplan Meier method gives us an overall 5-year survival rate of 88.14% with a mean survival of 58 months. Further 8 patients required repeat laserization either for residual or recurrence of lesion. Also 2 patients had a lymph node metastasis during the follow-up period. Thus, by applying Kaplan Meier method recurrence-free survival (RFS) and diseasefree survival was found to be 85.1% (mean: 55 months) and 73.34% (mean: 57 months respectively. Interestingly on applying Log Rank test it was observed that the site of the lip involvement, i.e. whether upper or lower had no infl uence on disease-free survival. It was also observed that history of tobacco intake did not infl uence the disease free survival either (Log Rank Test). Moreover the cosmetic results were excellent and with no signifi cant complication observed. ConclusionThe results reported here support the use of Nd:YAG laser for treatment of Stage I squamous cell carcinoma of lip in accordance with principles of minimal invasive and morbid surgery.

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Section: Discussionmentioning

confidence: 99%

“…Looking for any sign of fl ow away after fi lling the oral cavity with water checked the functional lip closure at the end of 3 months [3]. The integrity of facial nerve was evaluated in all the cases postoperatively using House Brackmann classifi cation [4].…”

Section: Methodsmentioning

confidence: 99%

Nd:YAG laser therapy of carcinoma lip (stage I squamous cell carcinoma): a retrospective evaluation

Singh

Tiwari

Shukla

et al. 2009

Indian J Otolaryngol Head Neck Surg

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“…For early-stage primary tumors of the oral cavity or oropharynx, a CR rate of 85% at 1 year, decreasing to 77% at 2 years, is reported [69,70], with an even higher CR rate of 96% for lip carcinoma [71].…”

Section: Head and Neck Cancermentioning

confidence: 99%

Photodynamic Therapy in Oncology

Triesscheijn¹,

et al. 2006

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Photodynamic therapy (PDT) is increasingly being recognized as an attractive, alternative treatment modality for superficial cancer. Treatment consists of two relatively simple procedures: the administration of a photosensitive drug and illumination of the tumor to activate the drug. Efficacy is high for small superficial tumors and, except for temporary skin photosensitization, there are no long-term side effects if appropriate protocols are followed. Healing occurs with little or no scarring and the procedure can be repeated without cumulative toxicity. Considering the efficacy and lack of long-term toxicity of PDT, and the fact that the first treatment of cancer with PDT was done more than 100 years ago, one might expect that this treatment had already become an established therapy. However, PDT is currently offered in only a few selected centers, although it is slowly gaining acceptance as an alternative to conventional cancer therapies. Here, we show the developmental steps PDT underwent and summarize the current clinical applications. The data show that, when properly used, PDT is an effective alternative treatment option in oncology. The

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“…Today, there are several indications and various techniques to use PDT in the head and neck [8,11,21]. The low morbidity and functional disturbances that result from PDT offer many advantages in the treatment of recurrent cancer in particular.…”

Section: Fig 2 Récidive D'un Carcinome éPidermoïde Du Voile Du Palamentioning

confidence: 99%

“…The basis of PDT is the combination of a photosensitizer (Foscan ® in our study) and light which causes a cytotoxic effect to cancerous tissue. The biological effects of PDT are primarily mediated either by the generation of reactive oxygen species, such as singlet oxygen ( 1 O 2 ) or by the production of oxygen free radicals which cause tumour cell death by intracellular oxygenation and vascular shutdown mechanisms [8]. Foscan ® (metatetra(hydroxyphenyl) chlorine: mTHPC) (Fig.…”

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confidence: 99%

Photodynamic therapy as salvage treatment for recurrent head and neck cancer

Gangloff

Phulpin

Cortese

et al. 2012

Med Buccale Chir Buccale

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-Head and neck cancers often lead to disfiguration or functional impairments after treatment. Local recurrence occurs in around 60% of cases and most of them can not be retreated. Photodynamic therapy (PDT) can be an alternative treatment. In a serie of 10 patients with recurrent squamous cell carcinoma of the head and neck that have failed prior therapies and are unsuitable for conventional curative therapy, PDT treatment has been used. Eight patients have shown complete cicatrisation. Seven patients were cured after the follow up period up to 53 months. Three patients died (one outside etiology). Quality of life was considered as very much for 6 out of 10 patients, quite a bit for 1 patient, a little for 2 patients and not at all for 1 patient. Clinical benefit was evaluated as very much for 6 patients out of 10, quite a bit for 2 patients, a little for 1 patient and not at all for 1 patient. PDT can be proposed to patients with head and neck cancer in palliative situation. It could be a therapeutic solution for selected cases with good outcomes. PDT offers patients a unique chance of remission and increased life expectancy compared with palliative treatments.Résumé -La thérapie photodynamique comme traitement de sauvetage pour les récidives des cancers des voies aéro-digestives supérieures. Les cancers de la tête et du cou conduisent souvent à des séquelles esthétiques ou fonctionnelles majeures après traitement. Des récidives locales sont observées dans environ 60 % des cas et la majorité ne peut pas être retraitée à nouveau. La thérapie photodynamique (PDT) peut être une possibilité de prise en charge alternative. Dans une série de 10 patients présentant une récidive d'un carcinome épidermoïde des voies aéro-digestives supérieures qui n'est plus accessible à traitement curatif conventionnel, la PDT a été utilisée. Huit patients ont montré une cicatrisation complète. Sept patients étaient considérés comme guéris après une période de surveillance allant jusqu'à 53 mois. Trois patients sont décédés (dont un d'une cause extérieure au contexte carcinologique). La qualité de vie a été considérée comme très bonne pour 6 patients sur 10, bonne pour 1 patient, moyenne pour 2 patients et mauvaise pour 1 patient. La PDT est une option thérapeutique qui peut être proposée aux patients atteints de cancers des voies aéro-digestives supérieures et placés en situation de prise en charge palliative. Cela pourrait être une possibilité de prise en charge pour des patients bien sélectionnés qui permettrait d'obtenir de bons résultats. La PDT a offert à ces patients une chance unique de rémission de la maladie et a amélioré indéniablement le taux de survie par rapport à la prise en charge palliative qui était la seule alternative.Key words: head and neck cancer / photodynamic therapy / salvage therapy / photosensitizers / squamous cell carcinoma

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Treatment of squamous cell carcinoma of the lip using Foscan-mediated Photodynamic Therapy

Cited by 95 publications

References 23 publications

Nd:YAG laser therapy of carcinoma lip (stage I squamous cell carcinoma): a retrospective evaluation

Nd:YAG laser therapy of carcinoma lip (stage I squamous cell carcinoma): a retrospective evaluation

Photodynamic Therapy in Oncology

Photodynamic therapy as salvage treatment for recurrent head and neck cancer

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