Treatment of squamous cell carcinoma of the eyelid with imiquimod 5% cream

Abstract

histopathology and immune histochemical aspects of the ductal tumours-they did not mention the outcome of the disease in that patient. 2 Similarly, there are two other reports describing the orbital metastasis in case of a mixed parotid tumour and polymorphous low-grade adenocarcinoma of the parotid glands. 3,4 After orbital exenteration, the examination of the specimen under the microscope revealed a larger poorly differentiated tumour mass eroding the ocular coats with a posterior extension invading the proximal part of the optic nerve; however, the resected posterior end of the optic nerve and rest of the margins were free of tumour cells. Immunological stains for cytokeratin, epithelial membrane antigen, and cytokeratin 7 were positive, whereas reactivity for S-100 proteins, estrogen receptors, progesterone receptors were negative. To conclude, the primary salivary duct carcinoma of the salivary gland remained asymptomatic clinically as well as radiologically for 18 months. Thus orbital tumours with unusual presentations need a detailed evaluation with close follow-up to counter the problems related to a primary tumour elsewhere in the body at the earliest, thereby helping to reduce systemic morbidity and mortality.

Tumor Clearance and Immune Cell Recruitment in UV‐Induced Murine Squamous Cell Carcinoma Exposed to Ablative Fractional Laser and Imiquimod Treatment

“…2C) and weaker immune cell recruitment following treatment with imiquimod alone (data not shown). However, several weeks of topical imiquimod treatment are generally necessary to produce a therapeutic effect in patients with SCC [35,36]. These results suggest that the strength of the immune cell recruitment may depend on the length of treatment and the study model.…”

Long-term efficacy and safety of imiquimod 5% and fluorouracil 1% creams in medical monotherapy of complex eyelid basal cell carcinomas

“…We have published this treatment regimen in our report to treat a squamous cell carcinoma of the eyelid with imiquimod cream. 2 The Fluorouracil, 1% cream, was used as twice daily each day as a thin layer. The use of 2% hydroxypropylmethylcellulose eye-gel was advised before the periocular application of either cream.…”

“…1 This planning depends on local factors like the involved length of the eyelid, complex anatomical sites (canthi, eyelid margins), and the patient's willingness as well as systemic fitness for surgery. 1,2 Extensive staged surgeries and general anesthesia are challenges in the elderly population who frequently have systemic co-morbidities like hypertension, coronary artery disease, and use blood-thinners. Furthermore, the aesthetic and functional eyelid reconstruction becomes equally critical and exigent.…”

“…Recently, immunotherapy with 5% imiquimod cream has demonstrated good outcomes in the actinic keratosis and superficial BCC of eyelids. [2][3][4][5][6][7][8] imiquimod is an immuneresponse modifier imidazoquinoline with a potent antitumor and anti-viral activity. 8 It has been used successfully for various dermatological conditions like viral warts and BCC.…”

Imiquimod‐side effects in the treatment of periocular skin cancers: A review of the literature

“…Demographic information, tumor characteristics, type of management and clinical outcomes of patients treated with periocular IMQ have been summarized (Table 1). [1][2][3][4][5][6][7][8][9] A total of 175 patients was reported (109 males, 61 females, 5 not specified 3 ) with a mean age of 71.27 years old (range 9-95 years). Overall, 180 periocular lesions treated with IMQ have been counted: 106 BCCs, 41 AK, 20 MIS, 11 Bowen's diseases, and 2 cSCCs.…”