Treatment of sporotrichosis and black fungus infections. With special reference to the mechanism of action of potassium iodide in sporotrichosis.

The ultrastructural changes produced by iodine-potassium iodide solution on yeast cells of Sporothrix schenckii were investigated by transmission electron microscopy in order to clarify the mechanism of oral potassium iodide therapy for sporotrichosis. Yeast cells were dipped with solutions containing various concentrations of iodine. The rate of germination decreased markedly between the range of iodine concentrations from 0.63 microgram/ml to 5.0 micrograms/ml. No significant ultrastructural changes were seen at the concentration of the iodine of 1.25 microgram/ml (80% germination) or less. In the concentration of 2.5 micrograms/ml (50% germination), normal cells and degenerated cells coexisted. When the cells were treated with 5.0 micrograms of iodine per ml (0% germination) or more, their interior structures were completely destroyed. It is assumed that iodine treatment of the organism causes rapid destruction in the whole cell.

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Ultrastructure of Sporothrix schenckii treated with iodine-potassium iodide solution

Hiruma

Kagawa

1987

Mycopathologia

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An unusual case of sporotrichosis and a statistical survey 1974-1987 at our university hospital.

Suzuki¹,

Aihara²,

Serikawa³

et al. 1990

Nishinihon J Dermatol

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Treatment of sporotrichosis and black fungus infections. With special reference to the mechanism of action of potassium iodide in sporotrichosis.

Cited by 2 publications

References 7 publications

Ultrastructure of Sporothrix schenckii treated with iodine-potassium iodide solution

Ultrastructure of Sporothrix schenckii treated with iodine-potassium iodide solution

An unusual case of sporotrichosis and a statistical survey 1974-1987 at our university hospital.

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