“…Bleeding disorders were mainly noted as those that impair the hemostatic mechanism including leukemia, hemophilia, thrombocytopenia, cryoglobulinemia, hemorrhagic diathesis, and polycythemia. Although less common, cases of spontaneous sSDH have been reported in the following conditions: ankylosing spondylitis [ 17 , 42 ], systemic lupus erythematosus [ 43 ], fibromuscular dysplasia [ 24 ], cystic fibrosis [ 44 ], polycystic kidney disease [ 25 ], chronic renal failure [ 34 ], rhabdomyolysis [ 31 ], rheumatoid arthritis [ 32 ], pregnancy [ 45 ], and eclampsia [ 46 ]. Although an underlying coagulopathy, anticoagulant therapy, or an iatrogenic cause can be implicated in most cases of spontaneous sSDH, a significant proportion of patients have no readily identifiable cause; thus further investigation of these cases is warranted.…”