Treatment of spinal cord injury by transplantation of fetal neural precursor cells engineered to express BMP inhibitor

Setoguchi, Takao; Nakashima, Kinichi; Takizawa, Takumi; Yanagisawa, Makoto; Ochiai, Wataru; Okabe, Masaru; Yone, Kazunori; Komiya, Setsuro; Taga, Tetsuya

doi:10.1016/j.expneurol.2003.12.007

Cited by 162 publications

(137 citation statements)

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“…Blocking Smad4 might not be sufficient to block mesenchymal fate in embryonic stem (ES) cells, but does promote neuronal fate (Sonntag et al, 2005). Spinal cord neurogenesis is promoted by inhibition of BMP signaling through expression of Noggin (Setoguchi et al, 2004). Extraembryonic endodermal fate of stem cells is inhibited and neuronal precursor fate is induced in other experimental systems by similar inhibition of signaling by BMP2 using noggin expression (Pera et al, 2004).…”

Section: Tgf-b and Neural Stem Cells (Nscs)mentioning

confidence: 99%

TGF-β, Neuronal Stem Cells and Glioblastoma

Golestaneh

Mishra

2005

Oncogene

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Transforming growth factor beta (TGF-b) signaling leads to a number of biological end points involving cell growth, differentiation, and morphogenesis. Typically, the cellular effect accompanies an induction of mesodermal cell fate and inhibition of neural cell differentiation. However, during pathological conditions, these defined effects of TGF-b can be reversed; for example, the growthinhibitory effect is replaced with its tumor promoting ability. A multitude of factors and cross-signaling pathways have been reported to be involved in modulating the dual effects of TGF-b. In this review, we focus on the potential role of TGF-b signal transduction during development of neural progenitor cells and its relation to glioblastoma development from neural stem cells.

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Section: Tgf-b and Neural Stem Cells (Nscs)mentioning

confidence: 99%

TGF-β, Neuronal Stem Cells and Glioblastoma

Golestaneh

Mishra

2005

Oncogene

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“…Several preclinical models of CNS pathology have demonstrated the utility of genetically engineered NSCs for improving functional neurological outcomes [12][13][14][15][16]. Recent data prove that transplantation of NSCs engineered to release insulin-like growth factor (IGF-1) reduced plaque pathology and enhanced learning, cognitive and memory processes in a mouse model…”

Section: Introductionmentioning

confidence: 99%

Part I: Minicircle vector technology limits DNA size restrictions on ex vivo gene delivery using nanoparticle vectors: Overcoming a translational barrier in neural stem cell therapy

Fernandes

Chari

2016

Journal of Controlled Release

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Please cite this article as: Alinda R. Fernandes, Divya M. Chari, Part I: Minicircle vector technology limits DNA size restrictions on ex vivo gene delivery using nanoparticle vectors: Overcoming a translational barrier in neural stem cell therapy, Journal of Controlled Release (2016Release ( ), doi: 10.1016Release ( /j.jconrel.2016 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT

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“…Expression of BMPs increases in the spinal cord after injury, and inhibition of BMP signaling in injured cords expands the lesion volume and shows poor functional recovery (Enzmann et al 2005). However, there is evidence that BMP inhibition enhances axonal outgrowth and locomotor activity (Setoguchi et al 2004;Matsuura et al 2008). BMP receptor signaling following injury show a beneficial effect of BMPRIA, and not BMPRIB for wound repair (Sahni et al 2010).…”

Section: Injury and Repairmentioning

confidence: 99%