“…Although there is paucity of strong supporting evidence, several reviews have reported a trend for superiority of SED in alleviating some of the clinical signs and symptoms in Sjögren's 19 and non-Sjögren's dry eye disease, limbal epithelial stem cell deficiency, Graft-vs-Host-Disease, persistent epithelial defects, recurrent corneal erosions, post-refractive surgery, 20 and Stevens-Johnsons syndrome/toxic epidermal necrolysis. 21 A double masked RCT in 40 eyes 13 demonstrated improved tear film stability and patient comfort with SED, supported by three other case series in 123 eyes of 63 dry eye patients, 22 56 eyes of 28 patients, 23 and in 17 patients with graft-versus-host disease.…”