TREATMENT OF SEVERE EXPERIMENTAL RETROPERITONEAL HEMATOMA WITH HYPERTONIC NaCl, HYPERTONIC Na ACETATE OR ISOTONIC LACTATED RINGERS. EFFECTS ON BLOOD LOSS AND HEMODYNAMIC PARAMETERS

Silva, Luiz Eduardo; Coelho, I. J. C.; Franca, E. S. V.; Silva, M. Rocha e

doi:10.1097/00024382-199512001-00026

Cited by 2 publications

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“…Krausz (27) described a model of uncontrolled bleeding in rats in which a hypertonic bolus injection increased mortality because of renewed bleeding. However, Silva et al (28) demonstrated that a bolus of hypertonic solutions did not cause renewed bleeding in an experimental model of blood loss into an artificially produced retroperitoneal hematoma. Moreover, our study differs from the others because we did not use a fixed bolus injection but a slow and continuous infusion adjusted to restore CO. Our data show that this infusion strategy of hypertonic solutions obtains a progressive recovery of hemodynamics without arterial pressure peak increases.…”

Section: Discussionmentioning

confidence: 99%

Resuscitation from hemorrhagic shock: Experimental model comparing normal saline, dextran, and hypertonic saline solutions

Chiara

Pelosi

Brazzi

et al. 2003

Critical Care Medicine

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Section: Discussionmentioning

confidence: 99%

Resuscitation from hemorrhagic shock: Experimental model comparing normal saline, dextran, and hypertonic saline solutions

Chiara

Pelosi

Brazzi

et al. 2003

Critical Care Medicine

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“…Several studies have been carried out in experimental animals with uncontrolled hemorrhagic shock with a retroperitoneal bleeding [9,10], vascular injury with intraperitoneal bleeding [11,12], and bleeding of extremities [13].…”

Section: Introductionmentioning

confidence: 99%

Intraosseous Hypertonic Saline Solution for Resuscitation of Uncontrolled, Exsanguinating Liver Injury in Young Swine

Carrera

Pacheco²,

Caruso³

et al. 2004

Eur Surg Res

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Fluid resuscitation administered before hemorrhage control for trauma victims sustaining blunt abdominal injury is controversial. Prehospital fluid resuscitation is limited by difficulty in delivering large volumes of fluid in the field and time delays associated with gaining vascular access. Venous access is often a clinical dilemma in severely hypovolemic children. Intraosseous infusion is considered a useful technique for the administration of fluids in emergency situations when peripheral intravascular access is not possible. This study investigated the effectiveness of intraosseous versus intravenous infusion of hypertonic saline solution in an uncontrolled hemorrhagic shock swine model. We also tested the effect of the different sites of infusion on the intra-abdominal bleeding. Relevant hemodynamic parameters were monitored and blood samples were collected. After liver injury, 20 anesthetized immature pigs were randomized to three groups: intraosseous access, intravenous access and control. After 20 min of uncontrolled hemorrhage, the hypertonic saline solution begins in the intraosseous access and intravenous access groups of animals. Thirty minutes later, the animals were killed and intra-abdominal blood loss was measured. All the pigs presented lower pressures and lower cardiac output after 20 min of hemorrhagic shock. The intravenous and intraosseous access groups did not show a better hemodynamic performance after 10 min of fluid resuscitation. At the end of the experiment, all animals were hemodynamically similar without an improved answer to a fluid resuscitation. There were no significant differences between groups regarding intra-abdominal blood loss. It was concluded that the hypertonic saline solution in this experimental model did not promote hemodynamic improvement and there were no differences between the two sites of fluid resuscitation regarding intra-abdominal blood loss.

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TREATMENT OF SEVERE EXPERIMENTAL RETROPERITONEAL HEMATOMA WITH HYPERTONIC NaCl, HYPERTONIC Na ACETATE OR ISOTONIC LACTATED RINGERS. EFFECTS ON BLOOD LOSS AND HEMODYNAMIC PARAMETERS

Cited by 2 publications

References 0 publications

Resuscitation from hemorrhagic shock: Experimental model comparing normal saline, dextran, and hypertonic saline solutions

Resuscitation from hemorrhagic shock: Experimental model comparing normal saline, dextran, and hypertonic saline solutions

Intraosseous Hypertonic Saline Solution for Resuscitation of Uncontrolled, Exsanguinating Liver Injury in Young Swine

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