Treatment of Severe, Disabling Migraine Attacks in an Over-The-Counter Population of Migraine Sufferers: Results From Three Randomized, Placebo-Controlled Studies of the Combination of Acetaminophen, Aspirin, and Caffeine

Goldstein, Jerome; Hoffman, HD; Armellino, JJ; Battikha, JP; Hamelsky, SW; Couch, J. R.; Blumenthal, Harvey J.; Lipton, RB

doi:10.1046/j.1468-2982.1999.019007684.x

Cited by 49 publications

(37 citation statements)

References 10 publications

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“…The efficacy of caffeine and paracetamol in headache treatment is well recognized and has been used for this purpose for many years [10]. Although paracetamol is used in the treatment of mild PDPH, its prophylactic efficacy has not been studied.…”

Section: Discussionmentioning

confidence: 99%

Oral multidose caffeine-paracetamol combination is not effective for the prophylaxis of postdural puncture headache

Esmaoğlu

Akpinar

Uğur

2005

Journal of Clinical Anesthesia

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Section: Discussionmentioning

confidence: 99%

Oral multidose caffeine-paracetamol combination is not effective for the prophylaxis of postdural puncture headache

Esmaoğlu

Akpinar

Uğur

2005

Journal of Clinical Anesthesia

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“…51,52 Such combinations commonly incorporate up to 100 mg caffeine, which is thought to potentiate their efficacy and increase the speed of onset of pain relief. 51,52 Such combinations commonly incorporate up to 100 mg caffeine, which is thought to potentiate their efficacy and increase the speed of onset of pain relief.…”

Section: Analgesic Agentsmentioning

confidence: 99%

Migraine in Pregnancy

Das

Muhasseb

Loughney

2005

Fet. Matern. Med. Rev.

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Reference to people suffering bouts of severe headache with associated vomiting and visual aura may be found in texts that date back 5000 years but the first clear description of migraine as a distinct clinical entity was provided by Aretaeus of Cappadocia in the second century AD. Today, at least 80% of women experience headaches in adult life and in approximately a quarter of these cases the pain is recurrent and incapacitating. When each episode of headache lasts between 4 and 72 hours and is accompanied by nausea, vomiting, photophobia or phonophobia, the symptoms fulfil the International Headache Society's current definition of the syndrome called migraine, detailed in Table 1.

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“…Overall adverse effect rates were low in both groups and not statistically different. If those with severe and disabling migraine are extracted for analysis from these studies [14], then 172 subjects met these criteria with nearly equal numbers in the active and placebo groups. Pain relief, resolution of migraine-associated symptoms, and relief of disability were substantially, if not statistically, superior in the active treatment group for nearly all time-points and evaluation parameters.…”

Section: Combination Medicationmentioning

confidence: 99%

Do Over-the-counter medications help the physician manage migraine headache?

Freitag

2002

Current Science Inc

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The use of over-the-counter-medication in migraine treatment is commonplace. They are often used in addition to physician-prescribed medications and may be used without the full knowledge of the physician. Although considerable evidence suggests their efficacy in migraine treatment, they are rarely used to maximal levels of efficacy and safety. A review of the evidence for these treatments is important for cost effective, well-tolerated, and specific treatment of migraine headache.

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Treatment of Severe, Disabling Migraine Attacks in an Over-The-Counter Population of Migraine Sufferers: Results From Three Randomized, Placebo-Controlled Studies of the Combination of Acetaminophen, Aspirin, and Caffeine

Abstract: The nonprescription combination of AAC was well tolerated and effective.

Cited by 49 publications

References 10 publications

Oral multidose caffeine-paracetamol combination is not effective for the prophylaxis of postdural puncture headache

Oral multidose caffeine-paracetamol combination is not effective for the prophylaxis of postdural puncture headache

Migraine in Pregnancy

Do Over-the-counter medications help the physician manage migraine headache?

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