2017
DOI: 10.1016/j.jogc.2016.10.011
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Treatment of Secondary Vestibulodynia with Conjugated Estrogen Cream: A Pilot, Double-Blind, Randomized Placebo-Controlled Trial

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Cited by 12 publications
(11 citation statements)
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“…If further treatment is warranted, there is low‐quality evidence for the following topical treatments that were shown to reduce pain in pre to posttest studies (without a control group): gabapentin cream, 28 amitriptyline cream, 30 amitriptyline with baclofen cream, 29 ketamine‐amitriptyline cream, 31 conjugated equine estrogen cream, 33 and estradiol/testosterone cream. 32 …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…If further treatment is warranted, there is low‐quality evidence for the following topical treatments that were shown to reduce pain in pre to posttest studies (without a control group): gabapentin cream, 28 amitriptyline cream, 30 amitriptyline with baclofen cream, 29 ketamine‐amitriptyline cream, 31 conjugated equine estrogen cream, 33 and estradiol/testosterone cream. 32 …”
Section: Discussionmentioning
confidence: 99%
“…Conjugated equine estrogen 33 and estradiol/testosterone cream 32 increase the elasticity, thickness, and moisture of the vulvar epithelium. In a small‐sample double‐blind RCT of 20 women with PV, 33 equine conjugated estrogen showed no reduction in dyspareunia compared with the placebo cream control group. In a retrospective chart review of estradiol/testosterone cream for premenopausal women with PV, 32 vulvar pain was reduced pre‐ to post‐treatment.…”
Section: Treatments For Vulvar Pain and Dyspareuniamentioning
confidence: 99%
“…49 Local application of conjugated equine estrogen cream significantly reduced dyspareunia assessed by the McGill Pain Questionnaire, in a study with a small sample. 50 There was no significant reduction in pain after botulinum toxin type A injections. 51,52 Studies presented in Table 5 that examined conservative vulvodynia treatments showed that physical therapy, 53 manual perineal rehabilitation with lidocaine gel, 54 somatocognitive therapy, 55,56 itraconazole treatment, 57 and the online ACT program 17 reduced pain intensity during sexual intercourse and/or during a variety of other activities that cause vulvar pain.…”
Section: Physical Therapymentioning
confidence: 92%
“…Studies carried out with estrogens only, on the other hand, provide contrasting opinions. While the work of Bazin et al 28 failed to prove a significant improvement in the symptoms after the application of a conjugated equine estrogen cream, Langlais et al 29 demonstrated a substantial improvement in superficial dyspareunia. In light of the evidence, vulvodynia provoked by CHC cessation would benefit from the application of either estrogen‐only or estrogen‐testosterone topical treatment, which could even be considered as first‐line therapy 1 .…”
Section: Pharmacologic Optionsmentioning
confidence: 99%