Treatment of Seborrhoeic Dermatitis of the Scalp with Desonide 0.05% Solution

Abstract

Topical corticosteroids are commonly used for the short-term management of seborrhoeic dermatitis (SD) of the scalp. The aim of this study was to evaluate the effectiveness, tolerance and cosmetic acceptability of desonide 0.05% solution, whose alcohol-free formulation is innovative with respect to traditional corticosteroid lotions, in the treatment of SD of the scalp. For this purpose, 155 adult subjects applied on scalp lesions desonide once daily for 1 week, on alternate days for 3 weeks, and two times a week for 4 weeks. A significant reduction of the severity of erythema, scaling and pruritus was observed (P<0.001). Interestingly, during the phase of gradual reduction of weekly applications, results were frequently maintained or improved further. Twenty patients (13%) at 4 weeks and 85 patients (58%) at 8 weeks had their scalp SD cleared. Most patients regarded the overall effectiveness, tolerability and acceptability as satisfactory; patients who had previously used common steroid lotions expressed a positive judgment on desonide solution compared to the other lotions in terms of efficacy, acceptability, rapidity of action, tolerability and persistence of effects. In conclusion, our preliminary findings indicate that desonide 0.05% solution is suitable for the short-term management of scalp SD.

Comparison of Two Different Dosing Regimens with Lymecycline, in Association with Adapalene, in Inflammatory Acne

“…During the 8-week follow-up phase with adapalene monotherapy, the clinical results were maintained or further improved in most cases, highlighting the value of adapalene as maintenance treatment after successful therapy of inflammatory acne (8,I0). At the same time, the highly favourable tolerability profile of adapalene was also confirmed in our experience (5,6,8,11). Interestingly, at W24, patients in group B showed a significantly lower number of comedones than patients treated with group A regimen (p=0.034, Fig.…”

“…At the same time, the highly favourable tolerability profile of adapalene was also confirmed in our experience (5,6,8,11). Interestingly, at W24, patients in group B showed a significantly lower number of comedones than patients treated with group A regimen (p=0.034, Fig.…”

“…Adapalene is a retinoid agent indicated for the topical treatment of acne vulgaris, which is commonly used alone in mild forms or in combination with antibiotics in inflammatory acne. Thanks to additional antiinflammatory properties, adapalene has a favourable tolerability profile compared with other retinoids (5)(6).…”

“…Thanks to additional antiinflammatory properties, adapalene has a favourable tolerability profile compared with other retinoids (5)(6).…”

Treatment of Inflammatory Acne with a Combination Therapy with Lymecycline and Adapalene Followed by Maintenance Treatment with Adapalene

“…A multicenter, randomized, investigator-blinded study has demonstrated that Iymecycline plus adapalene combination treatment resulted in a significantly greater and faster decrease in the number of acneic lesions than lymecycline plus vehicle (20). These effects of combined therapy may have relevant practical implications in terms of patient's satisfaction and compliance (21)(22)(23). During the 3-month phase with adapalene monotherapy the clinical results were maintained or further improved in the majority of cases.…”