Treatment of sarcoptic mite infestation and mite hypersensitivity in pigs with injectable doramectin

Abstract

Thirty-two pigs were infested experimentally with Sarcoptes scabiei var suis and allocated randomly to a medicated group (injected intramuscularly with 300 micrograms doramectin/kg) or an unmedicated group (injected intramuscularly with 1 ml saline/33 kg). They were observed daily for 15 minutes for signs of pruritus, and the ear lesions were assessed and skin scrapings examined for mites on days 7, 14, 21 and 28 after treatment. In the 16 pigs treated with doramectin the ear lesions resolved completely within 14 days, no mites were recorded on 15 of them on day 7 or on any of them on days 14, 21 and 28; pruritus was greatly reduced from day 7 onwards (range 0 to 0-62 rubbing episodes per pig per day) and papular skin lesions were absent from 15 of the pigs at slaughter on day 28. In comparison, the ear lesions in the 16 unmedicated pigs failed to resolve in 15 of them. Mites were present on 15 of them at different times during the experiment; the numbers of rubbing episodes ranged from 0.88 to 4.65 per pig per day and all the pigs had papular skin lesions at slaughter. In the unmedicated pigs, both the degree of pruritus and the presence and severity of papular skin lesions at slaughter were greater in those with zero or low mite counts than in those with high mite counts.

Sarcoptes scabiei infestation of a donkey in the UK

“…Efficacy of a single dose of injectable doramectin in the treatment of S. scabiei infestation in cattle (Logan et al . 1993) and pigs (Cargill et al . 1996) has been demonstrated.…”

Elimination of Mange Mites Sarcoptes scabiei var. suisfrom Two Naturally Infested Danish Sow Herds Using a Single Injection Regime with Doramectin

“…The demonstration of dead mange mites in ear scrapings following day 0 was not surprising, even though mites were absent in experimental trials within 28 days following efficacious treatment [6,7]. The severity and chronic nature of the mange infestation in these 2 herds, as well as the total number of animals examined by scrapings following treatment (452 in Herd A and 918 in Herd B ) may provide the answer.…”

“…According to this study, the results from an experimental trial [6] and results reported in a field trial [17], the single injection strategy is effective when using doramectin.…”

“…In phamacokinetic studies [11] doramectin has also been shown to have a longer duration of activity than ivermectin. A single injection with doramectin has been shown to be effective in eliminating mange mites under experimental conditions [6,7]. It has recently been reported from Sweden [17] that mange was successfully eliminated from a 21-sow, naturally infested herd, using a single-injection programme with doramectin, and without treatment of the environment with an acaricide.…”

Sarcoptes-scabiei-var.-suis-Infektion: eine seroepidemiologische Studie mit Blut- und Kolostralmilchproben zur Überwachung und Zertifizierung der medikamentösen Tilgung der Räude in Schweinezuchtbetrieben

“…Seit der Einführung der breit wirksamen Antiparasitika wie Ivermectin (6,11,15,22,23) oder Doramectin (3,6,20) ist es heute möglich, die Räude in infizierten Betrieben als Alternative zur Totalsanierung mit dem SPF-Verfahren medikamentös zu tilgen (16,27). Sowohl die perorale als auch die parenterale Applikation unter strenger Einhaltung des vorgeschriebenen Behandlungsschemas, mit oder ohne zusätzliche lokale Waschbehandlung der Tiere und deren Umgebung, erbrachte in unseren Untersuchungen absolute Sanierungserfolge.…”