Treatment of ruptured cerebral aneurysms and vasospasm after subarachnoid hemorrhage

Suárez, José I.

doi:10.1016/s1042-3680(06)80007-0

Cited by 11 publications

(12 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, whereas there is clear evidence for KCNQ1, KCNQ4 and KCNQ5 expression at the mRNA and protein level, as well as function in murine vascular contractility (Mackie et al, 2008; Yeung et al, 2007), no evidence has been found so far for expression there of KCNQ2 or KCNQ3. Thus, these data are consistent with a role for M channels in cerebral vasospasm, in which persistent constriction of cerebral arteries results in ischemic neurological deficits and consequential high morbidity and mortality (Rahimi et al, 2006; Suarez, 2006). Such a finding also underscores the emerging role of M-type currents as a neuroprotective mechanism during ischemic/hypoxic stroke (Boscia et al, 2006; Gamper et al, 2006), presenting a possible novel mode of therapeutic intervention against cerebrovascular events.…”

Section: Discussionsupporting

confidence: 83%

Distribution of M-channel subunits KCNQ2 and KCNQ3 in rat hippocampus

et al. 2011

View full text Add to dashboard Cite

Neuronal M-channels are low threshold, slowly activating and non-inactivating, voltage dependent K+ channels that play a crucial role in controlling neuronal excitability. The native M-channel is composed of heteromeric or homomeric assemblies of subunits belonging to the Kv7/KCNQ family, with KCNQ2/3 heteromers being the most abundant form. KCNQ2 and KCNQ3 subunits have been found to be expressed in various neurons in the central and peripheral nervous system of rodents and humans. Previous evidence shows preferential localization of both subunits to axon initial segments, somata and nodes of Ranvier. In this work, we show the distribution and co-localization of KCNQ2 and KCNQ3 subunits throughout the hippocampal formation, via immunostaining experiments on unfixed rat brain slices and confocal microscopy. We find intense localization and colocalization to the axonal initial segment in several regions of the hippocampus, as well as staining for non-neuronal cells in the area of the lateral ventricle. We did not observe colocalization of KCNQ2 or KCNQ3 with the presynaptic protein, synaptophysin.

show abstract

Section: Discussionsupporting

confidence: 83%

Distribution of M-channel subunits KCNQ2 and KCNQ3 in rat hippocampus

et al. 2011

View full text Add to dashboard Cite

show abstract

“…3 Other causes for aSAH are arteriovenous malformations, perimesencephalic hemorrhages, trauma, tumors, and infections. 3 Other causes for aSAH are arteriovenous malformations, perimesencephalic hemorrhages, trauma, tumors, and infections.…”

Section: Epidemiology Of Asah and Seizuresmentioning

confidence: 99%

Seizures and CNS Hemorrhage

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Initially, endovascular treatment was preferred for patients with higher surgical morbidity, those with poor medical conditions for surgery and those who refused surgery (3). The first randomized controlled study was the International Subarachnoid Aneurysm Trial (ISAT), which compared clipping and endovascular treatment in patients with intracranial aneurysms.…”

mentioning

confidence: 99%

Thirteen-year experience with coil embolization of 481 ruptured intracranial aneurysms: angiographic and clinical results

Dinç

Öztürk²,

Sarı³

et al. 2012

Diagn Interv Radiol

View full text Add to dashboard Cite

, 481 patients with ruptured aneurysms were referred for endovascular treatment with detachable coils at our center. The technical feasibility, procedural complications, morbidity, mortality, and initial angiographic and clinical results were evaluated. RESULTSEndovascular treatment was successful in 95.6% of the patients. Postembolization angiography showed complete occlusion in 63.4%, a neck remnant in 30.8%, and incomplete occlusion in 5.8% of the aneurysms. A total of 331 patients were followed up. The overall angiographic results showed stable occlusion in 234 aneurysms (70.7%) and recurrence in 97 aneurysms (29.3%). During the follow-up period, stable angiographic occlusion was evident in 75% of the small, 61% of the large, and 38.5% of the giant aneurysms. Complications during the coiling procedure occurred in 75 procedures (15.6%). Ischemic complications were observed in 33 procedures (6.9%), and perforation of the aneurysm during the coiling occurred in 12 cases (2.5%). Five (41.7%) of 12 patients who had perforation during coiling died. The overall procedure-related morbidity and mortality were 5.6% and 2%, respectively. During the follow-up period, two patients (0.4%) had early rebleeding. None of the patients showed late rebleeding. In the follow-up, the retreatment rate was 12.6%. CONCLUSION Our data confirm the feasibility, safety, and efficacy of endovascular coil embolization in patients with ruptured cerebral aneurysms.

show abstract

Treatment of ruptured cerebral aneurysms and vasospasm after subarachnoid hemorrhage

Cited by 11 publications

References 50 publications

Distribution of M-channel subunits KCNQ2 and KCNQ3 in rat hippocampus

Distribution of M-channel subunits KCNQ2 and KCNQ3 in rat hippocampus

Seizures and CNS Hemorrhage

Thirteen-year experience with coil embolization of 481 ruptured intracranial aneurysms: angiographic and clinical results

Contact Info

Product

Resources

About