Treatment of roentogenographically occult endobronchial carcinoma with external beam radiotherapy and intraluminal low dose rate brachytherapy

Saito, Mari; Yokoyama, Akira; Kurita, Yuichi; Uematsu, Takayoshi; Miyao, Hiromi; Fujimori, Katsuya

doi:10.1016/0360-3016(95)02390-9

Cited by 35 publications

(8 citation statements)

References 9 publications

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“…Although the treatment was described as “low-dose rate,” it was low to intermediate range (2 Gy per hour at a 5 mm depth and >2 Gy per hour at <5 mm depths). [ 8 ] We decided to go with a dose of 7 Gy x 4 after careful evaluation of pros and cons of higher doses associated with complications.…”

Section: Discussionmentioning

confidence: 99%

Radiologically Occult Lung Cancer Curatively Treated with High-Dose Rate Endobronchial Brachytherapy

Singh

Aujla

Nead

et al. 2021

JCIS

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Most patients diagnosed with early-stage non-small cell lung cancer (NSCLC) can be easily cured with surgery or stereotactic body radiotherapy (SBRT). Modalities such as photodynamic therapy, cryotherapy, or laser therapy only offer temporary palliation. A 79-year-old gentleman with early-stage NSCLC who underwent a left lower lobe lobectomy in 2009 presented to us again in 2010 with hemoptysis. A friable ~5 cm tumor along the bifurcation of anterior and the posterior segment of the right upper lobe was noted on bronchoscopic examination, and biopsy confirmed this to be squamous cell carcinoma. Because of his previous surgery, the patient was not a candidate for another surgery. SBRT was not possible as the lesion could not be seen on radiologic imaging. The patient was, therefore, treated with curative intent high-dose rate endobronchial brachytherapy (HDR-EBBT) in 4 weekly sessions of 7 Gy per fraction delivered at a depth of 8 mm, covering ~5 cm tumor plus 1 cm margin proximally and distally. He tolerated the treatment well without any acute or late side effects and was followed every 3 months thereafter with bronchoscopy examinations for 6 months and subsequently with computerized tomography (CT) imaging. In July 2018, the patient started having episodes of hemoptysis and evaluation leads to diagnosis of a third primary lung cancer, which was successfully treated with SBRT with image-guided radiotherapy using a five-fraction regimen. The patient’s most recent CT from July 2019 showed no evidence of disease. We conclude that in patients with early-stage NSCLC, when surgery or SBRT is not feasible due to radiologic occult nature, HDR-EBBT can yield excellent long-term outcome.

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Section: Discussionmentioning

confidence: 99%

Radiologically Occult Lung Cancer Curatively Treated with High-Dose Rate Endobronchial Brachytherapy

Singh

Aujla

Nead

et al. 2021

JCIS

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“…The JLCS defined early lung cancers as tumors that fulfill the following criteria: 1) chest X-ray findings are normal, 2) no lymph node or distant metastases are detectable using common methods for cancer staging, 3) the lesion is localized between the trachea and subsegmental bronchus, 4) the distal margin of the lesion is endoscopically visible, 5) the lesion is less than 2 cm in diameter, and 6) histologically, the lesion is squamous cell carcinoma [2]. Early lung cancer is located at sites that can be directly viewed through a bronchoscope; therefore, many surgeons recommend noninvasive treatments such as photodynamic therapy and endobronchial brachytherapy [3,4]. The patient’s poor general condition and presence of multiple lesions are good indications for these therapies [5].…”

Section: Discussionmentioning

confidence: 99%

Bronchial sleeve resection for early-stage squamous cell carcinoma

Goto

Maeshima

Akanabe

et al. 2012

J Cardiothorac Surg

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A 75-year-old man complained of sputum and was referred to our department. His sputum cytology was class III. Chest X-ray and computed tomography showed no abnormalities, but bronchoscopy revealed an elevated lesion in the membranous portion of the left main bronchus, which was pathologically diagnosed as squamous cell carcinoma in situ. Since bronchoscopy revealed no other lesions in the visible parts of the airway, it was considered to be a solitary, early lung cancer, and sleeve resection of the left main bronchus was performed. The postoperative pathological diagnosis was squamous cell carcinoma in situ, pTisN0M0, stage 0. In recent years, an increasing number of studies have reported photodynamic therapy and brachytherapy for the treatment of early lung cancer. However, aggressive bronchoplastic surgery with emphasis on curability should be considered for lesions that are deemed resectable based on their number and extent of invasion.

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“…This method can be irradiated to be deeper than the bronchial mucous layer [157,158]. A further number of cases and the term of the surveillance are necessary to evaluate effectiveness.…”

Section: Reviewmentioning

confidence: 99%

Early detection and screening of lung cancer

Mascaux

Peled

Garg

et al. 2010

Expert Review of Molecular Diagnostics

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Accounting for 28% of all cancer deaths and causing 1.3 million deaths worldwide every year, lung cancer is the most lethal cancer. Diagnosing and treating cancer at its early stages, ideally during precancerous stages, could increase the 5-year survival rate by three- to four-fold with a potential for cure. Thus far, no screening method has been shown to decrease disease-specific mortality rate. The present review describes the rationale and issues related to early lung cancer screening, the management of screen-detected primary cancers and different approaches that have been tested for screening. These include imaging techniques, bronchoscopies, molecular screenings from different noninvasive or invasive sources, such as blood, sputum, bronchoscopic samples and exhaled breath.

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Treatment of roentogenographically occult endobronchial carcinoma with external beam radiotherapy and intraluminal low dose rate brachytherapy

Abstract: The combination treatment of external beam radiotherapy and intraluminal brachytherapy is effective for roentogenographically occult endobronchial carcinoma with acceptable complications.

Cited by 35 publications

References 9 publications

Radiologically Occult Lung Cancer Curatively Treated with High-Dose Rate Endobronchial Brachytherapy

Radiologically Occult Lung Cancer Curatively Treated with High-Dose Rate Endobronchial Brachytherapy

Bronchial sleeve resection for early-stage squamous cell carcinoma

Early detection and screening of lung cancer

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