Treatment of retroperitoneal kaposiform hemangioendothelioma: 2 case reports

Li, Kai; Xiao, Xianmin; Dong, Kuiran; Wang, Zuopeng

doi:10.1016/j.epsc.2015.05.008

Cited by 4 publications

(2 citation statements)

References 15 publications

(4 reference statements)

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“…Contrast-enhanced MRI may also be used to assist diagnosis; (5) for patients with above symptoms and imaging manifestations, if with accompanied KMP and the condition is critical, surgical biopsy can be performed after improvement of coagulation and infusion of platelets. If biopsy is not feasible due to the condition, clinical judgement could be made based on previous diagnosis and treatment experience, and diagnostic treatment with drugs could be performed; (6) if the effect of single drug therapy is unsatisfactory, a combination therapy could be considered.…”

Section: Discussionmentioning

confidence: 99%

Retroperitoneal kaposiform hemangioendothelioma with kasabach-merritt phenomenon in children: A case report and review of the literature

Huo

Chen²,

Li³

et al. 2023

Front. Pediatr.

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ObjectiveTo investigate the clinical features, diagnosis and treatment methods and prognosis of retroperitoneal Kaposiform hemangioendothelioma (R-KHE) in children.MethodsThe clinical data of an infant with R-KHE was retrospectively analyzed. Literature on R-KHE in pediatrics were retrieved in databases including Wanfang, CNKI and PubMed as of April 2022.ResultsA 1 month and 6 days female infant with R-KHE was reported. After the diagnosis was confirmed by biopsy and pathological examination, the patient was treated by interventional embolization, and a combined therapy with glucocorticoid, vincristine, sirolimus and propranolol. The patient has been followed up for 1 year and 2 months, and is still alive with tumor. Through literature search, a total of 15 children, together with the case in our report, were included. The main manifestations were diversity among those patients. 14 cases have combined Kasabach-Merritt phenomenon (KMP). 6 cases accepted surgery plus drug therapy. 4 cases accepted only surgery, and 4 cases only accepted drug therapy. While drug therapy plus radiotherapy were employed to 1 case. Improvement was observed in 11 cases, with significantly reduced tumor and survival with tumor. Tumor disappeared completely in 2 cases. While 2 cases suffered death.ConclusionR-KHE has diverse clinical presentations and non-specificity in symptoms and imaging examinations, and most cases accompanied with KMP. Methods for R-KHE treatment include surgical resection, interventional embolization and drug therapy. Close attention needs to be paid to the adverse reactions of the drug during the course of treatment.

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Section: Discussionmentioning

confidence: 99%

Retroperitoneal kaposiform hemangioendothelioma with kasabach-merritt phenomenon in children: A case report and review of the literature

Huo

Chen²,

Li³

et al. 2023

Front. Pediatr.

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“… 1 Diagnosis can be further complicated when noncutaneous lesions are located within the retroperitoneum, and are often misdiagnosed as other pediatric retroperitoneal tumors, such as neuroblastoma. 5 Age of onset is usually in the first year of life, with a mean age of presentation at 2 months of age, and about half of cutaneous KHE lesions are noted at birth. 1 The majority of cutaneous KHE lesions present as a rapidly enlarging, firm, purpuric mass and are often associated with KMP.…”

Section: Discussionmentioning

confidence: 99%