Treatment of Renal Nephroblastoma in an Adult Dog

Seaman, R; Patton, Clark S.

doi:10.5326/0390076

Cited by 30 publications

(24 citation statements)

References 9 publications

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“…22 This finding corroborates the previous reports of nephroblastomas in dogs up to 8 years of age. 4,17,23 As in previous reports, presenting complaints and clinical signs were nonspecific and included polyuria/ polydipsia, vomiting, and behavior changes. 4 It has been previously reported that an abdominal mass could be palpated in as many as 43% of cases of renal tumors.…”

Section: Discussionmentioning

confidence: 58%

Primary Renal Neoplasia of Dogs

et al. 2006

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Section: Discussionmentioning

confidence: 58%

Primary Renal Neoplasia of Dogs

et al. 2006

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“…However, polycythemia has been reported infrequently, and is now recognized as part of paraneoplastic syndromes [6,8,9,11,16]. Other paraneoplastic syndromes of canine renal neoplasia include fever, hypercalcemia, marked neutrophilia, and HO [9,11,14,15].…”

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confidence: 99%

“…The treatment for HO is to resolve the underlying primary disease and to symptomatically treat any pain and discomfort or other clinical signs [1,5,7,14]. Usually, the proliferated bone change will regress in 2 to 5 weeks after elimination of the underlying cause [5,7,14,15].…”

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confidence: 99%

Hypertrophic Osteopathy Associated with Disseminated Metastases of Renal Cell Carcinoma in the Dog: A Case Report

Chiang

Liu

et al. 2007

The Journal of Veterinary Medical Science

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ABSTRACT. A 6-year-old, mixed breed, intact male dog showed signs of left carpal joint swelling and weakness of the forelimbs one month before presentation. The symptoms gradually progressed to bilateral carpal and tarsal joint swelling and tetraparalysis. There were a number of radiographically identified lytic-proliferative bone lesions noted on the axial skeleton. Hypertrophic osteopathy of the metacarpi and all distal long bones was also evident. Because of the deteriorating quality of life and guarded prognosis, the patient was euthanized and a complete necropsy was performed. Renal cell carcinoma, with metastasis to the lung, thoracic vertebrae, ribs, and the right adrenal gland, was diagnosed. To our knowledge, renal cell carcinoma with bone metastases and hypertrophic osteopathy has not been reported in dogs. KEY WORDS: canine, hypertrophic osteopathy, renal cell carcinoma.J. Vet. Med. Sci. 69(2): 209-212, 2007 Primary renal neoplasia occurs infrequently in dogs, with a prevalence rate of 0.3 to 2% of all canine neoplasia [4,9,10,11,13]. Of these, renal cell carcinoma (RCC) is the most common type [6,9,11,17] and is believed to originate from the epithelium of the proximal convoluted tubules. RCC generally occurs in older (reported average age of 8 years old) male dogs [6,13,16], with no obvious breed predisposition. Here we report an unusual case of canine RCC with disseminated metastases and hypertrophic osteopathy (HO).A 6-year-old, mixed breed, intact male dog was referred for evaluation of tetraparalysis. The patient was not on a regular vaccination program, but was under routine heartworm prevention. A month before presentation, the patient started to show signs of left carpal joint swelling and weakness of the forelimbs. The symptoms gradually progressed to bilateral carpal and tarsal joint swelling and tetraparalysis. An episode of hematuria had also been noted. Upon presentation the patient was anorexic and whining painfully.The patient presented with pale mucosal membranes and was cachexic, with 7% dehydration, tachycardia (150 /min), and tachypenia (60 /min). A right heart murmur was auscultated and graded as IV/VI. The patient was lying on his side, unable to stand or walk, but still with intact neurological reflexes and sensations on all four limbs. The distal parts of all limbs were swollen and firm. Multiple firm masses were palpated under the skin on both sides of the chest wall.Blood tests performed by the referring clinic showed leukocytosis (24300 cells/µl), and normocytic, normochromic anemia (packed cell volume: 27.6%, mean corpuscular volume: 65.7 fl, mean corpuscular hemoglobin: 23.3 pg). The blood total calcium concentration value was within normal limit (8.2 mg/dL). Radiographic findings of the chest showed extensive new bone formation on the bodies of the 4th, 5th, and 6th thoracic vertebrae. Lytic-proliferative bone lesions of variable size were also noted on the right 11th, 13th and the left 4th, 5th, 6th, 12th ribs (Fig. 1), and the upper margin of the right scapula. Exten...

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“…There are around 20 reported cases of renal nephroblastoma in the veterinary literature (table 5). More recent reports recently had increased survival times, compared with those previously reported (>19,3 >254 and >30 months5). Treatment has varied between cases from nephrectomy alone to nephrectomy with adjunctive chemotherapy (table 5).…”

Section: Discussionmentioning

confidence: 72%

Renal nephroblastoma in a 10‐month‐old boxer

Richardson

2020

Vet Record Case Reports

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A 10-month-old male entire Boxer dog was presented for weight loss and abdominal distension with a large mass palpable within the abdomen. A unilateral nephrectomy was performed for a large renal nephroblastoma (30-cm diameter). The nephroblastoma was suspected stage I, with favourable histology (human Wilms tumour grading). No adjunctive chemotherapy was administered. The dog remains clinically well 27 months postnephrectomy. Renal nephroblastomas are rare canine neoplasms and reported survival time is variable. This case and other recent reports suggest that mean survival time may be longer than previously thought. Nephroblastomas should be considered as a differential in young dogs presenting with clinical signs of an abdominal space-occupying lesion. The absence of azotaemia on a biochemical profile does not preclude significant renal pathology.

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Treatment of Renal Nephroblastoma in an Adult Dog

Cited by 30 publications

References 9 publications

Primary Renal Neoplasia of Dogs

Primary Renal Neoplasia of Dogs

Hypertrophic Osteopathy Associated with Disseminated Metastases of Renal Cell Carcinoma in the Dog: A Case Report

Renal nephroblastoma in a 10‐month‐old boxer

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