Treatment of Recurrent Primary Cutaneous Mucinous Carcinoma of the Eyelid with Modified Wide Local Excision

Abstract

Primary cutaneous mucinous carcinoma (PCMC) is a rare, low-grade malignant neoplasm of the sweat gland, whose history has been controversial regarding eccrine versus apocrine origin. This case report describes a 53-year-old male who presented to the University of Florida, Gainesville, ophthalmology clinic and was referred to the oculoplastics service with a painless, subcentimeter mass on the lateral right upper eyelid including the canthus, consistent with recurrent primary cutaneous mucinous carcinoma of the eyelid. Four years prior, the patient had undergone excisional biopsy of the lesion in a clinic, which revealed residual tumor, but the patient deferred further surgery at the time. The patient underwent surgical excision of the mass with reconstruction without operative complications and with negative surgical margins. PCMC is difficult to diagnose clinically due to its rarity and requires a histopathological examination for confirmation of the diagnosis. This report presents the first case in the literature of primary cutaneous mucinous carcinoma in a patient with human immunodeficiency virus (HIV). With this case report, we aim to raise awareness of primary cutaneous mucinous carcinoma as a potential part of the differential diagnosis for malignant eyelid lesions, including those present in patients with HIV.

Primary mucinous skin cancer: A case report and review of the literature

“…6,7 Anatomically, the eyelid is the most commonly affected site (41%), followed by the scalp (17%), face (14%), axilla (9%), chest/abdomen (7%), vulva (4%), neck (2%), extremity (2%), canthus (2%), groin (1%), and ear (1%). [8][9][10] Our case was a 62-year-old man who falls into a few subgroups as a facial lesion.…”

Primary Cutaneous Mucinous Carcinoma of the Eyelid: A Case Report

“…There is difficulty in distinguishing this primary neoplasm from metastatic mucinous carcinoma of non-cutaneous origin with primary sites in the lungs, breast, colon, and ovaries [5,6]. These tumors have a higher male predominance and occur more frequently in the elderly [1,3,7]. It commonly arises from the head and neck region, mostly found in the eyelid (38%), but also occurs on the face (20.3%) and scalp (16%) [1,3].…”

“…It commonly arises from the head and neck region, mostly found in the eyelid (38%), but also occurs on the face (20.3%) and scalp (16%) [1,3]. It is also known to have locally aggressive features and a high recurrence rate [7].…”

Painless eyelid nodule

“…Histology shows a dermal tumor consisting of fibrous septae delineating pools of mucin with collections of basophilic epithelioid cells. 1 Sebaceous carcinoma – Incorrect. While sebaceous carcinoma may clinically appear similar to mucinous carcinoma, the 2 can be differentiated histologically.…”

“…Histology shows a dermal tumor consisting of fibrous septae delineating pools of mucin with collections of basophilic epithelioid cells. 1 …”