Treatment of recurrent conjunctival papillomatosis with mitomycin C

Resolution of recurrent conjunctival papilloma after topical and intralesional interferon α2b with partial excision in a child

“…The use of subconjunctival or perilesional injection and topical IFN a2b for primary corneal and conjunctival intraepithelial neoplasia has shown impressive rates of disease resolution over varying follow-up periods. 9 The first report of use of interferon for the conjunctival papilloma with its complete resolution dates back to 1987. 9 A 6-month course of 5 million units/m 2 was used intramuscularly daily for 1 month and then 2 or 3 times weekly for 5 months.…”

“…Subconjunctival injection of IFN a2b (2 cc, 6 million units/mL) with topical IFN a2b and mitomycin C was effective in a child with multifocal recurrences and multiple debulking surgeries. 9 Topical IFN a2b was used as an adjunct to the surgical excision / systemic IFN a2b in the reports from 1990 through 2009. 5 However, Schechter and colleagues 4 and Falco and colleagues in 2007, 10 reported complete resolution of conjunctival papilloma with topical IFN a2b alone.…”

Oral Cimetidine Adjuvant Therapy for Recalcitrant, Diffuse Conjunctival Papillomatosis

“…Dramatic tumor remission was achieved by a treatment duration of 4 months. Hawkins et al 6 reported a case of a 5-year-old African American girl with recurrent papilloma of the palpebral conjunctiva after excision, cryotherapy, and IFN injection. She received tumor excision combined with intraoperative 0.3 mg/mL mitomycin C soaking for 3 minutes because of tumor recurrence.…”

Conjunctival Intraepithelial Neoplasia – Clinical Presentation, Diagnosis and Treatment Possibilities

“…Approximately, 9% of CIN treated with subconjunctival and/or topical INF alpha 2b showed recurrences, and 33 % of them were successfully retreated with topical IFN alpha 2b (Huerva & Magues, 2008). Another one (16,6%) achieved complete remission after intraperioperative MMC (Hawkins et al, 1999). For INF alpha 2b topical treatment, the average time to complete tumor response is 11 weeks (range 2-59).…”