Treatment of recalcitrant Darier's disease with electron beam therapy

Kittridge, Ashley; Wahlgren, Christina; Fuhrer, Russell; Zirwas, Matthew J.; Patton, Timothy

doi:10.1111/j.1529-8019.2010.01327.x

Cited by 9 publications

(15 citation statements)

References 10 publications

(13 reference statements)

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“…Two recent experiences described the efficacy of electron beam radiotherapy in Darier's disease [14, 15]. The first [14] used a dose of 2 Gy daily with energy of 7.5 MeV generated by a linear accelerator.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of the Radiotherapy on Darier’s Disease: An Indirect Evidence

Podgornii¹,

Ciammella²,

Ramundo³

et al. 2013

Case Reports in Dermatological Medicine

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Darier's disease (DD) is an autosomal dominant dermatosis characterized by hyperkeratotic papules that are mainly located in the seborrheic areas and pushups, handheld wells, and nails. The disease often appears at a young age, typically by the third decade, with no sex predilection. There is currently no standard therapy and there are usually topical palliative therapies. We present the case of an affected 42-year-old woman treated with radiation therapy for early breast cancer. Before the radiotherapy, the patient showed hyperkeratotic, brownish papules extending in a linear pattern for the neck to the abdomen, especially on both breasts and inframammary area. During the radiation, she developed grade 1 to 2 dermatitis in the irradiated area. At a followup of 6 months, the patient has no skin lesions in the irradiated zone. This report suggests that the radiotherapy is not contraindicated and may indeed be effective in local control of skin lesions in DD.

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Section: Discussionmentioning

confidence: 99%

“…At the followup, the irradiated areas remained without recurrence, whereas new lesions in untreated body sites developed. The second study [15] reported a case of severe DD that was poorly responsive to known therapeutic modalities. This patient was treated with a total dose of 20 Gy in 10 fractions using 6 MeV electrons.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of the Radiotherapy on Darier’s Disease: An Indirect Evidence

Podgornii¹,

Ciammella²,

Ramundo³

et al. 2013

Case Reports in Dermatological Medicine

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“…antibiotics (11), oral retinoid (acitretin or alitretinoin) (12)(13), ciclosporin (14)(15) and, more recently, lowdose naltrexone (16)(17)(18). Interventional treatments may also be performed, including (19): dermabrasion (20), wide excision (21), laser ablation (22)(23)(24), photodynamic therapy (25)(26)(27) and radiotherapy (28)(29).…”

Section: Introductionmentioning

confidence: 99%

Botulinum Toxin Injections as an Effective Treatment for Patients with Hailey-Hailey or Darier Disease: An open-label 6-month pilot interventional study

Dreyfus

Maza

Rodriguez

et al. 2020

Preprint

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Background: Patients with Hailey-Hailey and Darier diseases present with disabling inflammatory lesions located in large skin folds, which are often exacerbated or induced by sweating. Quality of life is highly impaired because of pain and recurrent skin infections. An improvement in skin lesions after botulinum toxin A injections has previously been reported in some patients but no prospective interventional studies are available. The aim of this open-label, 6-month, interventional pilot study (NCT02782702) was to evaluate the effectiveness and safety of botulinum toxin A injections. Thirty patients with moderate to very severe skin lesions located in folds were enrolled in the study. Results: Thirty patients (26 Hailey-Hailey / 4 Darier) were included. Botulinum toxin A proved effective within the first month in two-thirds of patients, taking all study parameters (itchiness, cutaneous pain, sweating and odour, infections, psychosocial impairment and quality of life) into account and persisted during the 6-month follow-up period. No patient was classed as a BtxA non-responder, but 11 (37%) patients, who were the most severe ones, experienced a relapse during the study. No serious side effects were reported. Mild transient clear fluid discharge at the site of the injections was reported for 27% of patients. Conclusions: Botulinic toxin is an effective and safe treatment for Hailey-Hailey and Darier diseases. Further studies should evaluate the benefit of increased doses or combined treatments for the most severe patients.Timing of approvals:- 25, February 2015: approval by the institutional ethics committee- 2, June 2015: registration under the European Eudract identifier 2015-000379-29 (https://eudract.ema.europa.eu/index.html)- 31, July 2015: approval by the French national health authority, ANSM - 31, August 2015: implementation agreement signed by the sponsor. - 25, May 2016: registration under the ClinicalTrials.gov identifier NCT02782702 (https://clinicaltrials.gov/ct2/show/NCT02782702?cond=NCT02782702&draw=2&rank=1).

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“…Oral retinoids lead to improvement in approximately 90% of patients with severe disease (Engin et al, ). For recalcitrant localized disease, ablative techniques can be successful (Kittridge, Wahlgren, Fuhrer, Zirwas, & Patton, ; Lindelof, ). We present a patient with refractory DD with excellent response to three different modalities of radiation therapy: electron beam, intensity modulated radiation therapy (IMRT), and brachytherapy.…”

Section: Introductionmentioning

confidence: 99%

“…Oral retinoids lead to improvement in approximately 90% of patients with severe disease (Engin et al, 2015). For recalcitrant localized disease, ablative techniques can be successful (Kittridge, Wahlgren, Fuhrer, Zirwas, & Patton, 2010;Lindelof, 1987).…”

Section: Introductionmentioning

confidence: 99%