Treatment of Radiation-Induced Gastrointestinal Distress With Acetylsalicylate

Mennie, A. T.; Dalley, VeraM.; Dinneen, L. C.; Collier, H. O. J.

doi:10.1016/s0140-6736(75)90358-x

Cited by 158 publications

(42 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In view of the pharmacological properties of prostaglandins, it is possible that they contribute to some of the signs of radiation sickness, such as diarrhoea, nausea and pain. Mennie, Dalley, Dinneen & Collier (1975) have therefore examined the effect of inhibition of prostaglandin synthesis by acetylsalicylate in patients with gastrointestinal distress caused by radiotherapy. Abdominal pain, flatulence and bowel motions were significantly reduced.…”

Section: Discussionmentioning

confidence: 99%

Effect of Ionizing Radiation on Prostaglandin‐like Activity in Tissues

Eisen

Walker

1976

British J Pharmacology

View full text Add to dashboard Cite

One to 7 days after whole body exposure of mice to a single dose of 700 R of x‐rays, little or no change was detected in prostaglandin‐like activity in the brain, blood and seminal vesicles. Slight increases in intestinal and renal tissue were not significant. In the lung, mean activity rose from 62 ng/g to a transient peak of 145 ng/g wet weight on the fourth day (P > 0.05). In the spleen, mean levels rose steadily from 13.2 ng/g to 259 ng/g on the fourth day (P < 0.01), and were still 184.4 ng/g on the seventh day. Prostaglandin‐like activity was measured 4 days after single doses of 200–700 R. In the lung, a significant rise was produced by 600 and 700 R, and in the spleen by 200–700 R. Thin layer chromatography showed that part of the prostaglandin‐like activity in spleen extracts had an RF similar to that of [3H]‐prostaglandin E1, and part to that of [3H]‐prostaglandin F2α. Splenic tissue from mice exposed to 700 R four days earlier, inactivated prostaglandin E1 less potently than did tissue from non‐irradiated mice.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Ionizing Radiation on Prostaglandin‐like Activity in Tissues

Eisen

Walker

1976

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…Indeed, only one randomized, controlled trial has been performed so far, showing that mesalazine significantly improved symptoms such as diarrhea, abdominal pain and flatulence [40] . However, radiotherapy techniques have completely changed since the 70 s, thus the results of the above mentioned trial might not be suitable to present day.…”

Section: Aminosalicylatesmentioning

confidence: 99%

Pelvic radiation disease: Updates on treatment options

Frazzoni

Marca

Guido

et al. 2015

WJCO

View full text Add to dashboard Cite

Pelvic cancers are among the most frequently diagnosed neoplasms and radiotherapy represents one of the main treatment options. The irradiation field usually encompasses healthy intestinal tissue, especially of distal large bowel, thus inducing gastrointestinal (GI) radiation-induced toxicity. Indeed, up to half of radiationtreated patients say that their quality of life is affected by GI symptoms (e.g. , rectal bleeding, diarrhoea). The constellation of GI symptoms -from transient to longterm, from mild to very severe -experienced by patients who underwent radiation treatment for a pelvic tumor have been comprised in the definition of pelvic radiation disease (PRD). A correct and evidence-based therapeutic approach of patients experiencing GI radiation-induced toxicity is mandatory. Therapeutic non-surgical strategies for PRD can be summarized in two broad categories, i.e. , medical and endoscopic. Of note, most of the studies have investigated the management of radiation-induced rectal bleeding. Patients with clinically significant bleeding (i.e. , causing chronic anemia) should firstly be considered for medical management (i.e. , sucralfate enemas, metronidazole and hyperbaric oxygen); in case of failure, endoscopic treatment should be implemented. This latter should be considered the first choice in case of acute, transfusion requiring, bleeding. More well-performed, high quality studies should be performed, especially the role of medical treatments should be better investigated as well as the comparative studies between endoscopic and hyperbaric oxygen treatments.

show abstract

“…Clinically, the use of elemental diets (58,(70)(71)(72), low-fat diets (73)(74)(75), manipulation of bacterial flora (76), anti-inflammatory drugs (77,78), bile acid sequestering resins (79), or enteroprotective drugs (80) during the course of radiation therapy appear to ameliorate symptoms of acute intestinal injury, and possibly also the severity of damage. Other prophylactic measures include surgical exclusion of the small bowel from the pelvis prior to irradiation for pelvic neoplasms by the use of polyglycolic acid mesh (81-84) omentum (85-87), bladder (88), or various types of 'spacers' (89)(90)(91).…”

Section: Late Radiation Enteropathymentioning

confidence: 99%

Late Radiation Injury of the Small Intestine Clinical, pathophysiologic and radiobiologic aspects: A review

Hauer‐Jensen

1990

Acta Oncologica

View full text Add to dashboard Cite

Treatment of Radiation-Induced Gastrointestinal Distress With Acetylsalicylate

Cited by 158 publications

References 11 publications

Effect of Ionizing Radiation on Prostaglandin‐like Activity in Tissues

Effect of Ionizing Radiation on Prostaglandin‐like Activity in Tissues

Pelvic radiation disease: Updates on treatment options

Late Radiation Injury of the Small Intestine Clinical, pathophysiologic and radiobiologic aspects: A review

Contact Info

Product

Resources

About