Treatment of rabbit carotid aneurysms by hybrid stents (microporous thin polyurethane-covered stents): Preservation of side-branches

Abstract

ObjectiveWe sought to determine the patency of normal arterial branches from the covered segments of an artery after stenting.BackgroundMost intracranial aneurysms occur at arterial branching points (bifurcations, side-branches, or perforators). The post-stenting patency of normal arterial branches from the covered segments of the artery is important. We have previously developed a hybrid stent with micropores to prevent early parent artery occlusion by more early endothelialization, and mid- to long-term parent artery stenosis by control of intimal hyperplasia after aneurysm occlusion.MethodsWe created aneurysms in 10 rabbits by distal ligation and intraluminal incubation of elastase within an endovascularly trapped proximal segment of the common carotid artery. All animals were treated with hybrid stents having micropores. Four animals were observed for one month and three each for three and 12 months. The patency of the side-branches of the subclavian artery was evaluated angiographically and in some cases, histologically.ResultsAneurysms were completely occluded at all time points other than 12 months. The subclavian artery and brachiocephalic artery were patent, without significant stenosis. All the side-branches of the subclavian artery detected on the preoperative angiogram remained patent at the final assessment.ConclusionThe use of hybrid stents for aneurysm repair and side-branch patency seems to be effective, as per the long-term results obtained in an animal model.

In vitro hydrodynamical study on aneurysmal morphology for treating intracranial aneurysms using particle imaging velocimetry

“…A stent with effective flowreduction properties leads to reliable IA embolization. However, excessive flow reduction was linked to an elevated risk of intimal thickening and side-branch occlusion in the region surrounding the stent [4,5].…”

Evaluating the safety and technical effectiveness of a newly developed intravascular ’flow isolator' stent for the treatment of intracranial aneurysms: study protocol for a first-in-human single-arm multiple-site clinical trial in Japan

“…At 2 months after stenting, the luminal surface was covered with complete thin neointimal formation. In addition, even in the prototype model of the NCVC-CS1, all branches were patent in a rabbit subclavian artery model 9. Therefore, it is highly likely that the NCVC-CS1 could be appropriate for the treatment of vertebral targets incorporating the posterior inferior cerebellar artery and the basilar artery.…”

How to create a nervous system aneurysm model in canines? ligation of the lingual artery is a simple and effective method

“…With the development of neuro-interventional techniques, various endovascular interventional techniques and materials are gradually applied in clinical practice. The nervous system aneurysm model was initially used to research the embolic effectiveness of coils, and later, it was also used to detect blood flow steering devices, and stent-grafts ( Kallmes et al, 1999 ; Hans et al, 2003 ; Nishi et al, 2014 ; Kim et al, 2016 ). Therefore, the establishment of a simple, stable, and reliable model of nervous system aneurysm is extremely important for the research of its hemodynamics, histopathological changes, and the research and evaluation of various treatment strategies.…”