Treatment of Pyoderma Gangrenosutn with Cultured Keratinocyte Autografts

Lı́mová, Markéta; Mauro, Theodora M.

doi:10.1111/j.1524-4725.1994.tb03715.x

Cited by 37 publications

(7 citation statements)

References 30 publications

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“…Surgical treatment with stoma relocation is associated with a high chance of recurrence, but stoma closure has been associated with no recurrence . Recent studies showed promising results with newer therapies such as cultured keratinocyte autografts, topical sucralfate, topical crushed prednisone, and biologic treatment …”

Section: Preexisting Skin Diseases Account For Approximately 20% Of Pmentioning

confidence: 99%

Peristomal skin complications: what dermatologists need to know

2017

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A stoma is an artificial opening to the skin formed when a part of the gastrointestinal tract is resected and opened to the skin in order to divert the bowel content to the skin surface. The incidence of stomal and peristomal complication varies from 30 to 67% with a significant negative impact on patient quality of life. Despite their prevalence, care providers tend to show insufficient awareness of peristomal skin complications, and research‐based evidence related to peristomal skin complication and management options particularly in dermatology literature is sparse. This article will present a comprehensive review of peristomal skin complications in classification, clinical presentation, causes, prevention, and management aiming at increasing knowledge about this topic.

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Section: Preexisting Skin Diseases Account For Approximately 20% Of Pmentioning

confidence: 99%

Peristomal skin complications: what dermatologists need to know

2017

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“…Surgical procedures such as debridement should be avoided, since they may cause extension of the lesions and further tissue damage [71, 72]. Skin graft [73, 74], intravenous immunoglobulin [75] or plasmapheresis [76] have been useful in isolated cases.…”

Section: Discussionmentioning

confidence: 99%

Infliximab for the Treatment of Disseminated Pyoderma Gangrenosum Associated with Ulcerative Colitis

Juillerat¹,

Christen-Zäch

Troillet³

et al. 2007

Dermatology

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We report the case of a 19-year-old woman who developed an acute disseminated pyoderma gangrenosum (PG) during a severe flare of ulcerative colitis (UC). She was successfully treated with a 3-dose regimen of the anti-tumor-necrosis-factor-α antibody infliximab. The literature on the effectiveness of this biological agent was reviewed, including 8 other cases of UC-associated PG and 77 cases of Crohn’s-disease-associated PG. This case report and the review of the literature demonstrate that infliximab can be successfully used to treat patients with PG associated with inflammatory bowel diseases.

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“…Although it is not considered standard therapy, CEA is one of many treatment modalities for ulcers. Cultured epithelial autografts successfully treated ulcerating leg wounds of several etiologies in a study of 86 variable ulcers among 36 patients 34 . Ulcers treated with CEA healed in several weeks and displayed favorable cosmetic outcomes.…”

Section: Methodsmentioning

confidence: 99%

“…A case written by Límová and Mauro 38 detailed the use of CEA in a nonhealing foot ulcer due to pyoderma gangrenosum. The patient presented with a deep and necrotic ulcer on the dorsum of the foot thought to have originated from a brown recluse spider bite until histologically verified as pyoderma gangrenosum.…”

Section: Methodsmentioning

confidence: 99%

Clinical Indications of Cultured Epithelial Autografts

Dhar,

Chrisman,

Simman

2023

Ann Plast Surg

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Cultured epithelial autografts (CEAs) have been used for decades as a treatment for massive burn injuries. Cultured epithelial autografts allow for wounds to heal by taking a small sample and growing a patient's own epithelium in culture to create large, graftable sheets. This technique is especially useful in large wounds where donor sites are limited compared with conventional skin grafting. However, CEAs have a variety of uses in wound healing and reconstruction and have the potential to aid in the closure of several types of defects. Cultured epithelial autografts have shown applicability in large burns, chronic nonhealing wounds, ulcerating wounds of various etiologies, congenital defects, wounds requiring specialized epithelium to replace like by like, and wounds in critically ill patients. Several factors must be considered when using CEAs, such as time, cost, and outcomes. In this article, we detail the various clinical applications of CEAs and how they can be situationally advantageous outside of their original purpose.

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Treatment of Pyoderma Gangrenosutn with Cultured Keratinocyte Autografts

Abstract: Cultured keratinocyte autografts can provide permanent wound coverage for patients on high doses of immunosuppressive medications.

Cited by 37 publications

References 30 publications

Peristomal skin complications: what dermatologists need to know

Peristomal skin complications: what dermatologists need to know

Infliximab for the Treatment of Disseminated Pyoderma Gangrenosum Associated with Ulcerative Colitis

Clinical Indications of Cultured Epithelial Autografts

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