Treatment of Pseudomonas Keratitis in Humans*

Experimental Pseudomonas aeruginosa Infection of the Mouse Cornea

“…The corneal pathology persisted beyond the period of infection. Whereas no similar experiments have been reported previously, the results are consistent with the previous observations that corneal pathology is caused by the extracellular enzymes (3,5) and that such enzymes trigger a long-lasting progression of inflammatory-repair events (1). A greater understanding of the nature of the defense and repair is important to the design of future experiments on therapy and prophylaxis.…”

Subpalpebral Antibiotic Lavage for the Treatment of Refractory Infectious Scleritis

“…The flange was designed to sit in the forniceal cul-de-sac and provide continuous irrigation. 5 The described flange design makes it an excellent barrier against accidental explantation of the tubing; however, the single point of irrigation entry may limit drug delivery to a focal location, particularly when the eyelids are closed. The authors propose a fenestration design to ensure that the entire globe is continuously bathed in an antibiotic solution, regardless of the patient's head positioning.…”

Management of bacterial keratitis: beyond exorcism towards consideration of organism and host factors

“…Subconjunctival injections may be repeated every 12-24 h at separate sites during the initial 24-48 h. Continuous lavage of antibiotic may deliver a high concentration and mechanical irrigation to remove potential virulence factors. 87,88 Continuous lavage or infusion via a scleral contact lens (Mediflow) is costly and impractical because of the requirement of patient immobilization. In addition, such therapy may result in epithelial trauma, cumulative toxicity of the ocular surface, or systemic toxicity.…”