Treatment of prurigo nodularis with pregabalin

Abstract

In our study, pregabalin was effective for the treatment of PN. However, given the open and non-controlled study design used, a properly powered randomized controlled validation study is called for.

Prurigo nodularis: a physician survey to evaluate current perceptions of its classification, clinical experience and unmet need

“…1 The results of this survey also support the established finding that PN confers a heavy burden on patients and that these patients likely require more frequent use of healthcare resources. In line with what is reported in the literature, 8,25,26 respondents rated immunosuppressants and gabapentinoids as the most effective systemic treatments for pruritus in PN. Sleep disturbance has been demonstrated to have serious consequences, including poor health, missed workdays and doctor visits owing to other skin conditions.…”

“…Sleep disturbance has been demonstrated to have serious consequences, including poor health, missed workdays and doctor visits owing to other skin conditions. 2,[25][26][27][28][29] Of particular note is the use of antidepressants. 4,8,9 Treatment for PN is commonly standardized, and the goal of therapy is often to manage pruritus.…”

S2k Guidelines for the diagnosis and treatment of chronic pruritus – update – short version

“…With respect to nephrogenic pruritus, there is now sound evidence of the effi cacy of gabapentin and pregabalin. Moreover, case reports and one open non-controlled trial have shown that pregabalin -at a dose of 75-300 mg/day -may be effectively used in the treatment of PN-associated CP [ 28,29 ] .…”

“…In Fallberichten und einer offenen, nichtkontrollierten Studie konnte ferner dokumentiert werden, dass Pregabalin in einer Dosierung von 75-300 mg/d effektiv zur Therapie des CP bei PN eingesetzt werden kann[ 28,29 ] .Der Wirkmechanismus von Gabapentin und Pregabalin bei CP wird noch diskutiert und beruht möglicherweise auf einer Nervenmembranstabilisation durch die Blockade von Kalziumkanälen, Inhibition der Synthese des Neurotransmitters Glutamat oder durch Verstärkung GABAerger inhibitorischer Mechanismen[ 26 ] . Häufi g treten Übelkeit, Erbrechen, Schwindel oder Müdigkeit auf, die nach einigen Tagen abklingen (siehe hierzu Fachinformation).…”

Successful Treatment of Chronic Intractable Itching Using Oral Pregabalin in a Patient with Diabetes and Systemic Prurigo Nodularis: A Case Report of an Iliopsoas Muscle Abscess

“…The developmental pathways of pain and pruritus are similar (2). Furthermore, the efficacy of pregabalin for treating pruritus has been previously reported (2)(3)(4)(5). We herein present a case in which we prescribed pregabalin for the treatment of chronic intractable itching that led to repeated cutaneous infections.…”