Context: Whether focal therapy (FT) for prostate cancer (PCa) jeopardizes outcomes of salvage treatments is a matter of debate awaiting to be resolved. Objective: To review the literature investigating oncological and functional outcomes as well as complications of available treatment options for recurrent or residual disease after primary FT. Evidence Acquisition: We performed a non-systematic web search using pubmed, including all articles aiming at assessing relevant outcomes of salvage local treatment after FT failure. Web search was implemented by manual search. When no evidence could be extracted in the FT domain, records dealing with recurrence after whole-gland ablation were considered. Evidence Synthesis: four retrospective series assessed salvage treatments after FT failure evaluating cases of radical prostatectomy (RP) and redo ablation (included patients n=12-22). The studies' quality was low with a high risk of bias. Other options are radiation therapy (RT) and whole gland or focal redo ablations which, however, have only been described after whole-gland ablation. With some exceptions, including sexual function for RP, overall complications, oncological and functional outcomes do seem acceptable not being much worse than those of a primary setting. Important limitations include low level of evidence and absence of standardized criteria for FT, salvage treatment and FT failure. Conclusions: Current evidence shows acceptable outcomes of post-FT salvage options, although this is based on retrospective data. While it seems that FT has minimal impact on salvage treatment results, prospective controlled studies are needed to confirm this preliminary data.