Treatment of Precocious Pseudopuberty Associated With Ovarian Cysts

Lightner, Elmer S.; Kelch, Robert P.

doi:10.1001/archpedi.1984.02140400012002

Cited by 7 publications

(3 citation statements)

References 13 publications

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“…Our two subjects resemble previously reported patients with precocious puberty due to transient follicular cysts (17)(18)(19)(20). However, unlike our two girls, most of these patients had unsustained pubertal progression, and their clinical response to LHRH therapy was apparently not assessed.…”

Section: Discussionsupporting

confidence: 76%

Luteinizing Hormone-Releasing Hormone (LHRH)-Independent Precocious Puberty Unresponsive to LHRH Agonist Therapy in Two Girls Lacking Features of the McCune-Albright Syndrome

Feuillan

Jones

Oerter

et al. 1991

The Journal of Clinical Endocrinology & Metabolism

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Two girls with precocious puberty (chronological age, 1 and 4 yr; bone age, 3 and 6 yr, respectively) were initially given the diagnosis of idiopathic, central precocious puberty and treated with the LHRH agonist deslorelin (D-Trp6-Pro9-NEt-LHRH) for 5 yr. Unlike other girls with central precocious puberty, both had persistently elevated rates of growth and bone maturation, and both menstruated during therapy. One girl had episodic ovarian enlargement and markedly elevated serum estradiol levels due to recurrent unilateral ovarian cysts. Although the bone and skin manifestations of McCune-Albright syndrome were absent, we hypothesize that the underlying defect of McCune-Albright syndrome was expressed in the ovaries, but not in the skin or bones, of these two girls. One of these girls appeared to benefit from the aromatase inhibitor testolactone, which is effective in suppressing precocious puberty in girls with the McCune-Albright syndrome.

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Section: Discussionsupporting

confidence: 76%

Luteinizing Hormone-Releasing Hormone (LHRH)-Independent Precocious Puberty Unresponsive to LHRH Agonist Therapy in Two Girls Lacking Features of the McCune-Albright Syndrome

Feuillan

Jones

Oerter

et al. 1991

The Journal of Clinical Endocrinology & Metabolism

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“…Aberrant levels of metabolites are also linked with oxidative stress and changes in renal hemodynamics. Moreover, oxidative stress has been shown to play a significant role in podocyte damage, proteinuria, and tubulointerstitial fibrosis [ 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of diabetic nephropathy expression profile based on weighted gene co-expression network analysis algorithm

2021

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Background Diabetic nephropathy (DN) is the major complication of diabetes mellitus, and leading cause of end-stage renal disease. The underlying molecular mechanism of DN is not yet completely clear. The aim of this study was to analyze a DN microarray dataset using weighted gene co-expression network analysis (WGCNA) algorithm for better understanding of DN pathogenesis and exploring key genes in the disease progression. Methods The identified differentially expressed genes (DEGs) in DN dataset GSE47183 were introduced to WGCNA algorithm to construct co-expression modules. STRING database was used for construction of Protein-protein interaction (PPI) networks of the genes in all modules and the hub genes were identified considering both the degree centrality in the PPI networks and the ranked lists of weighted networks. Gene ontology and Reactome pathway enrichment analyses were performed on each module to understand their involvement in the biological processes and pathways. Following validation of the hub genes in another DN dataset (GSE96804), their up-stream regulators, including microRNAs and transcription factors were predicted and a regulatory network comprising of all these molecules was constructed. Results After normalization and analysis of the dataset, 2475 significant DEGs were identified and clustered into six different co-expression modules by WGCNA algorithm. Then, DEGs of each module were subjected to functional enrichment analyses and PPI network constructions. Metabolic processes, cell cycle control, and apoptosis were among the top enriched terms. In the next step, 23 hub genes were identified among the modules in genes and five of them, including FN1, SLC2A2, FABP1, EHHADH and PIPOX were validated in another DN dataset. In the regulatory network, FN1 was the most affected hub gene and mir-27a and REAL were recognized as two main upstream-regulators of the hub genes. Conclusions The identified hub genes from the hearts of co-expression modules could widen our understanding of the DN development and might be of targets of future investigations, exploring their therapeutic potentials for treatment of this complicated disease.

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“…GIPP may occur because of increased sex steroid secreted from the gonads or adrenals or from exposure to exogenous E2. Autonomous functional ovarian follicular cysts are the most common causes of GIPP [44]. In girls transient breast development and vaginal bleeding are the most common presentation, which can be an isolated event or recur at unpredictable levels.…”

Section: Gonadotropin Independent Precocious Puberty (Gipp)mentioning

confidence: 99%

A Review on Update on Diagnosis and Therapeutic Management of Precocious Puberty’’ - A long with A Case Report

Kaur¹

2017

OAJG

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Precocious Puberty (PP) is the attainment of secondary sex characters before the age of 8 in girls and 9 yrs in boys. It can be divided into Central PP(CPP)/True PP or Gonadotropin dependent PP and Gonadotropon independent PP(GIPP) or Pseudo PP. CPP is characterized by the premature activation of the hypothalamo-Pituitary-Gonadal Axis. Onset of secondary sex characteristics before age 8, which further progresses with increased growth velocity and bone age acceleration which ultimately ends in impaired adult height. Mutation studies have shown occasional mutations in KISS1. KISS1R, Makorin ring finger protein 3(MKRN3) genes as some of the genetic modifications. Treatment with Gonadotropin releasing hormone agonists remain the treatment of choice which helps in ultimate attainment of normal height till actual age of puberty. With further introduction of a yearly GnRH subcutaneous implant histerelin administration has become more convenient than the tedious monthly GnRH a in the form of leuprolide depot or decapeptyl depot. This review sums up the various causes of CPP and GIPP with an update of its management, differential diagnosis and a case report to highlight an example.

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Treatment of Precocious Pseudopuberty Associated With Ovarian Cysts

Cited by 7 publications

References 13 publications

Luteinizing Hormone-Releasing Hormone (LHRH)-Independent Precocious Puberty Unresponsive to LHRH Agonist Therapy in Two Girls Lacking Features of the McCune-Albright Syndrome

Luteinizing Hormone-Releasing Hormone (LHRH)-Independent Precocious Puberty Unresponsive to LHRH Agonist Therapy in Two Girls Lacking Features of the McCune-Albright Syndrome

Comprehensive analysis of diabetic nephropathy expression profile based on weighted gene co-expression network analysis algorithm

A Review on Update on Diagnosis and Therapeutic Management of Precocious Puberty’’ - A long with A Case Report

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