Treatment of Potassium Retention in Anuria With Cation Exchange Resin°

Elkinton, J. R.; Clark, John K.; Squires, Russell D.; Bluemle, Lewis W.; Crosley, Archer P.

doi:10.1097/00000441-195022050-00010

Cited by 66 publications

(10 citation statements)

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“…Since potassium was given to the former group alone, only this group exhibited a positive potassium balance (Table I). In the anuric group the negative potassium balance reached large proportions only in Patient I. C. to whom cation exchange resin ene- (12). In the anuric patients no significant exchanges of "excess" potassium took place, but in the polyuric patients potassium in excess of nitrogen entered the intracellular phase (Table II).…”

Section: Resultsmentioning

confidence: 97%

Intracellular Cation Exchanges in Acidosis Due to Renal Insufficiency. Effects of Alkali Therapy 1

Elkinton¹,

Squires²,

Singer³

1951

J. Clin. Invest.

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Disturbances in the exchanges of certain intracellular electrolytes which occur in patients with metabolic alkalosis, have been described in the previous paper (1). Clues to the direction and magnitude of these disturbances were obtained by calculating from balance measurements the alterations in body fluids produced by replacement therapy. In the present communication the results are presented of a similar study in patients with metabolic acidosis due to renal insufficiency.Since this study involved the administration of hypertonic solutions of sodium bicarbonate or sodium lactate, it seemed advisable to reassess all of the factors, including those of intracellular transfers, which determine the quantitative effect of such replacement therapy on the total fluid and acid-base equilibrium of these patients. Previous studies have been made of the effects of alkalinizing sodium solutions. Palmer and Van Slyke (2) and later Hartmann and Senn (3) found that the rise in serum bicarbonate was such that the dose of alkali was apparently distributed through a volume equal to two-thirds of the body weight, a fraction which they believed represented the total body water. Since both bicarbonate ions (4, 5) and the major portion of sodium ions are not freely diffusible across the cell membrane, some explanation must be sought for the discrepancy between the value stated above and the now commonly accepted

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Section: Resultsmentioning

confidence: 97%

Intracellular Cation Exchanges in Acidosis Due to Renal Insufficiency. Effects of Alkali Therapy 1

Elkinton¹,

Squires²,

Singer³

1951

J. Clin. Invest.

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“…No início da década de 1950, surgiram os primeiros relatos de sucesso no tratamento de hipercalemia com resinas trocadoras de cátions em insuficiência renal anúrica 3,4 . Em 1959 Palmer e cols.…”

Section: Históricounclassified

Resinas Trocadoras De Cátions Na Hipercalemia Aguda Grave

Pachaly

2014

Rev. Med. UFPR

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INTRODUÇÃOAs resinas trocadoras de cátions fazem parte da abordagem terapêutica tradicional da hipercalemia. As resinas de troca catiônica são substâncias sintéticas, não absorvíveis, que liberam um cátion que faz parte de sua composição e captam outro cátion de interesse, no caso, o potássio, causando a redução da calemia. As resinas disponíveis atualmente são: poliestireno sulfonato de sódio (PSS), nos Estados Unidos, e poliestireno sulfonato de cálcio (PSC), no Brasil. Grande parte da literatura encontrada sobre estas resinas é proveniente de países onde é utilizado o PSS, cuja sua estrutura química e efeitos são similares aos do PSC. Porém, como as resinas atualmente disponíveis são efetivas a partir de 24 horas de uso, não atendem à demanda pela remoção rápida de potássio, como ocorre na hipercalemia aguda com toxicidade cardíaca e manifestações eletrocardiográficas. Além disto, apesar de não serem absorvidas, as resinas não são substâncias inócuas, e podem causar complicações graves no aparelho digestivo.Decisões sobre o uso das resinas na hipercalemia aguda grave devem ser feitas com cautela e considerando o contexto de cada paciente. O objetivo desta revisão é trazer mais dados que permitam ao leitor uma visão crítica sobre o papel real destas substâncias no tratamento da hipercalemia aguda.

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“…14 Cation exchange resins in the sodium cycle have proved effective in treating potassium intoxication. 15 They may be given as oral mixtures alone or, preferably, with sorbitol to promote gastrointestinal emptying, or they may be used as enemas. 4 Both methods are effective.…”

Section: Managing the Catabolic Responsementioning

confidence: 99%

Management of Acute Renal Failure

Krehl

1961

Postgraduate Medicine

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Treatment of Potassium Retention in Anuria With Cation Exchange Resin°

Cited by 66 publications

References 0 publications

Intracellular Cation Exchanges in Acidosis Due to Renal Insufficiency. Effects of Alkali Therapy 1

Intracellular Cation Exchanges in Acidosis Due to Renal Insufficiency. Effects of Alkali Therapy 1

Resinas Trocadoras De Cátions Na Hipercalemia Aguda Grave

Management of Acute Renal Failure

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