Treatment of posttraumatic bone defects by the induced membrane technique

Karger, C.; Kishi, Taka; Schneider, L.; Fitoussi, Franck; Masquelet, A. C.

doi:10.1016/j.otsr.2011.11.001

Cited by 306 publications

(212 citation statements)

References 16 publications

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“…The two-step surgical procedure has an advantage in case of primary infection and where repeated debridement is necessary. The notion of a biological chamber which is described in this method provides a vast experimental field that needs further exploration [8].…”

Section: Resultsmentioning

confidence: 99%

“…The first step comprises soft tissue and bone debridement with implantation of a cement spacer that induces a pseudosynovial membrane, stabilization of the bony segment with a stable fixation, and soft tissue coverage or free tissue transfer. The second step is performed approximately 2 months later and comprises removal of the cement spacer and filling of the cavity with cancellous bone graft and bone substitutes [1][2][3].…”

Section: Discussionmentioning

confidence: 99%

“…Karger et al [8] have reported the largest case series that used this technique. This was a retrospective study which included 84 posttraumatic diaphyseal long bone reconstructions (61 tibias) of which 50% were infected.…”

Section: Discussionmentioning

confidence: 99%

“…IIlizarov technique, vascularized fibular grafts, and acute limb shortening have been used previously to address defects of various lengths. In 1986, A.C. Masquelet conceived and developed an original reconstruction technique for large diaphyseal bone defects, based on the notion of induced membrane [1]. The principle of the induced membrane technique involves provoking a foreign body reacts by placing a cement spacer in the bone defect.…”

Section: Introductionmentioning

confidence: 99%

“…This prevents graft resorption by inducing vascularization and provides growth factors, it is a two-step procedure. The first step includes an extensive excision of infected and non-viable tissue, it is followed by careful stabilization of the bone and placement of cement spacer in the bone defect .and covered with a flap if required .The second step is performed at least 6 to 8 weeks after the first step, it includes removing the spacer and filling the biological space which has been created with cancellous graft or bone substitutes [1][2][3][4].…”

mentioning

confidence: 99%

See 4 more Smart Citations

Masquelet Technique for Reconstruction of Extensive Bone Defect of Tibia after Gunshot Injury in a Child: Case Report

Fannouch¹,

Alfaisali²,

Bobseit³

et al. 2018

MOJOR

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Reconstruction of extensive traumatic bone loss in children especially after gunshot injury represents a complex and challenging clinical entity with significant long-term morbidity. In 1986, A.C. Masquelet conceived and developed an original reconstruction technique for large diaphyseal bone defects, based on the notion of the induced a pseudo-membrane, This technique will be described in our case report.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Masquelet Technique for Reconstruction of Extensive Bone Defect of Tibia after Gunshot Injury in a Child: Case Report

Fannouch¹,

Alfaisali²,

Bobseit³

et al. 2018

MOJOR

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Biomaterial‐Stabilized Soft Tissue Healing for Healing of Critical‐Sized Bone Defects: the Masquelet Technique

Tarchala

Harvey

Barralet

2016

Adv Healthcare Materials

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Critical-sized bone defects present a significant burden to the medical community due to their challenging treatment. However, a successful limb-salvaging technique, the Masquelet Technique (MT), has significantly improved the prognosis of many segmental bone defects in helping to restore form and function. Although the Masquelet Technique has proven to be clinically effective, the physiology of the healing it induces is not well understood. Multiple modifiable factors have been implicated by various surgical and research teams, but no single factor has been proven to be critical to the success of the Masquelet Technique. In this review the most recent clinical and experimental evidence that supports and helps to decipher the traditional Masquelet, as well as the modifiable factors and their effect on the success of the technique are discussed. In addition, future developments for the integration of the traditional Masquelet Technique with the use of alternative biomaterials to increase the effectiveness and expand the clinical applicability of the Masquelet Technique are reviewed.

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The masquelet induced membrane technique with BMP and a synthetic scaffold can heal a rat femoral critical size defect

Bosemark

Perdikouri

Pelkonen

et al. 2015

Journal Orthopaedic Research

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Long bone defects can be managed by the induced membrane technique together with autologous bone graft. However, graft harvest is associated with donor site morbidity. This study investigates if a tricalcium phosphate hydroxyapatite scaffold can be used alone or in combination with bone active drugs to improve healing. Sprague Dawley rats (n ¼ 40) were randomized into four groups. (A) scaffold, (B) BMP-7, (C) BMP-7 þ scaffold, and (D) BMP-7 þ scaffold þ systemic bisphosphonate at 2 weeks. Locked femoral nailing was followed by 6 mm segment removal and implantation of an epoxy spacer. At 4 weeks, the spacers were removed and the defects grafted. Eleven weeks later, the bones were explanted for evaluation with radiography, manual assessment, micro-CT, histology, and Fourier Transform Infrared spectroscopy (FTIR). Isolated scaffolds (A) did not heal any defects, whereas the other treatments led to healing in 7/10 (B), 10/10 (C), and 9/10 (D) rats. Group D had greater volume of highly mineralized bone (p < 0.01) and higher bone volume fraction (p < 0.01) compared to all other groups. A synthetic scaffold þ BMP-7 combined with a bisphosphonate improved the callus properties in a rat femoral critical size defect, compared to both BMP-7 and scaffold alone or the two combined.

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Treatment of posttraumatic bone defects by the induced membrane technique

Abstract: Level IV. Retrospective study.

Cited by 306 publications

References 16 publications

Masquelet Technique for Reconstruction of Extensive Bone Defect of Tibia after Gunshot Injury in a Child: Case Report

Masquelet Technique for Reconstruction of Extensive Bone Defect of Tibia after Gunshot Injury in a Child: Case Report

Biomaterial‐Stabilized Soft Tissue Healing for Healing of Critical‐Sized Bone Defects: the Masquelet Technique

The masquelet induced membrane technique with BMP and a synthetic scaffold can heal a rat femoral critical size defect

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