Treatment of postmastectomy lymphedema with low‐level laser therapy

Carati, Colin; Anderson, Sandy; Gannon, B. J.; Piller, Neil

doi:10.1002/cncr.11641

Cited by 156 publications

(171 citation statements)

References 24 publications

(31 reference statements)

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“…Since 1995, the use of LLLT for the treatment of BCRL has been investigated in humans and the U.S. Food and Drug Administration (FDA) accepted it as treatment option for BCRL in 2006 [32]. The proposed underlying mechanism is that LLLT increases the lymphatic drainage by stimulating the formation of new lymph vessels, by improving the lymphatic motricity, and by preventing the formation of fibrotic tissue [33][34][35][36].…”

Section: Lllt For the Management Of Bcrlmentioning

confidence: 99%

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

et al. 2016

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Breast cancer is the most common cancer in women worldwide, with an incidence of 1.7 million in 2012. Breast cancer and its treatments can bring along serious side effects such as fatigue, skin toxicity, lymphedema, pain, nausea, etc. These can substantially affect the patients' quality of life. Therefore, supportive care for breast cancer patients is an essential mainstay in the treatment. Low-level light therapy (LLLT) also named photobiomodulation therapy (PBMT) has proven its efficiency in general medicine for already more than 40 years. It is a noninvasive treatment option used to stimulate wound healing and reduce inflammation, edema, and pain. LLLT is used in different medical settings ranging from dermatology, physiotherapy, and neurology to dentistry. Since the last twenty years, LLLT is becoming a new treatment modality in supportive care for breast cancer. For this review, all existing literature concerning the use of LLLT for breast cancer was used to provide evidence in the following domains: oral mucositis (OM), radiodermatitis (RD), lymphedema, chemotherapy-induced peripheral neuropathy (CIPN), and osteonecrosis of the jaw (ONJ). The findings of this review suggest that LLLT is a promising option for the management of breast cancer treatment-related side effects. However, it still remains important to define appropriate treatment and irradiation parameters for each condition in order to ensure the effectiveness of LLLT.

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Section: Lllt For the Management Of Bcrlmentioning

confidence: 99%

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

et al. 2016

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“…Publication of the positive clinical effects of lowpower laser therapy, including lymphedema treatment, stimulated our interest in studying lymphatic response to this radiation [143][144][145] . The effects of low-power laser radiation (He-Ne laser) on intact lymph microvessels were studied at three radiation intensities-450 mW/cm 2 , 45 mW/cm 2 , and 14 mW/cm 2 -each with an exposure time of 15 min [66,136,146] .…”

Section: Effect Of Low-power Laser Irradiationmentioning

confidence: 99%

Advances in small animal mesentery models for in vivo flow cytometry, dynamic microscopy, and drug screening

Galanzha¹

2007

WJG

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Using animal mesentery with intravital optical microscopy is a well-established experimental model for studying blood and lymph microcirculation in vivo . Recent advances in cell biology and optical techniques provide the basis for extending this model for new applications, which should generate significantly improved experimental data. This review summarizes the achievements in this specific area, including in vivo label-free blood and lymph photothermal flow cytometry, super-sensitive fluorescence image cytometry, light scattering and speckle flow cytometry, microvessel dynamic microscopy, infrared (IR) angiography, and high-speed imaging of individual cells in fast flow. The capabilities of these techniques, using the rat mesentery model, were demonstrated in various studies; e.g., real-time quantitative detection of circulating and migrating individual blood and cancer cells, studies on vascular dynamics with a focus on lymphatics under normal conditions and under different interventions (e.g. lasers, drugs, nicotine), assessment of lymphatic disturbances from experimental lymphedema, monitoring cell traffic between blood and lymph systems, and high-speed imaging of cell transient deformability in flow. In particular, the obtained results demonstrated that individual cell transportation in living organisms depends on cell type (e.g., normal blood or leukemic cells), the cell's functional state (e.g., live, apoptotic, or necrotic), and the functional status of the organism. Possible future applications, including in vivo early diagnosis and prevention of disease, monitoring immune response and apoptosis, chemo-and radio-sensitivity tests, and drug screening, are also discussed. TOPIC HIGHLIGHT

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“…Ongoing research has been presented in treatments such as cold laser, electrical stimulation, vibratory therapy, oscillation therapy, endermologie and aqualymphatic therapy and are done in combination with portions of CDT (Piller et al, 2010;Carati et al, 2003;Hafner et al, 2005 ;Tidhar et al, 201;Omar et al, 2010;Jahr, et al, 2008). Acupuncture is shown to ease some cancer and treatment related symptoms such as fatigue, hot flashes, nausea, neuropathy, and muscular or joint pain, but no formal treatment has been devised from acupuncture (Farrow, 2010b).…”

Section: Pharmacological Complementary Integrative and Alternative Mmentioning

confidence: 99%

Arm Lymphedema as a Consequence of Breast Cancer Therapy

Wernicke¹,

Goltser²

2012

Novel Strategies in Lymphedema

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Lymphedema is a swelling caused by the abnormal accumulation of lymphatic fluid in the skin. Lymphedema can be caused by burns, injury, surgery, radiation therapy or cancer treatment that cancer survivors undergo. Risk of developing lymphedema is high especially in those with breast or prostate cancer. It is hereditary and can appear without warning at any time of life and is related to obesity and circulatory problems. If not treated, lymphedema can be painful and lead to life-threatening infections. This book will help physicians who deal with lymphedema. It will help you understand how the lymphatic system works, how lymphedema is diagnosed, how to cope with the challenges of lymphedema, how to find treatment, and how to deal with insurance issues.Novel Strategies in Lymphedema is for those with, or at risk of, developing lymphedema, and the healthcare professionals who care for them.

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Treatment of postmastectomy lymphedema with low‐level laser therapy

Abstract: The authors thank Ann Angel and Richard Walmsley for their support of, and contribution to, this project. They also gratefully thank all participants in the trial and Adrian Esterman, Department of Clinical Epidemiology at Flinders Medical Centre, for statistical assistance.

Cited by 156 publications

References 24 publications

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

Advances in small animal mesentery models for in vivo flow cytometry, dynamic microscopy, and drug screening

Arm Lymphedema as a Consequence of Breast Cancer Therapy

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