Treatment of post-traumatic hematoma and fibrosis using hyaluronidase injection

Han, Ji‐Hoon; Kim, Junekyu; Yoon, Kun Chul

doi:10.7181/acfs.2017.01396

Cited by 8 publications

(7 citation statements)

References 6 publications

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“…For several years, hyaluronidase has been used in various fields of medicine to minimize postoperative edema. Han et al 17 reported injecting hyaluronidase after hematoma and fibrosis due to facial trauma, which resulted in complete resolution of the hematoma, reduced fibrosis, and alleviation of pain. Because nasal bone fractures require surgery after edema is reduced, a considerable amount of time is required between the accident and surgery.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of local hyaluronidase administration in guided bone regeneration surgery: a randomized controlled trial

Kwoen

Choi

Kim

et al. 2021

JKAOMS

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Objectives Hyaluronoglucosaminidase (hyaluronidase) increases the local intercellular permeability of the peripheral lymphatic channel and capillaries, which may help reduce edema. In the present study, the effects of hyaluronidase on postoperative edema and pain reduction were evaluated. Materials and Methods The study included 38 patients who underwent guided bone regeneration (GBR) surgery before implantation. Patients were randomly assigned to either the control group (n=20) or the test group (n=18). Hyaluronidase was injected into the GBR site of subjects in the test group. Postoperative edema was evaluated by measuring the distance between specific facial landmarks immediately after surgery (T1) and 2-4 days after surgery (T2). The degree of pain at T2 and at 10-14 days after surgery (T3) was assessed. Results In the test group, the degree of swelling was lower than in the control group, however, only two measurements, from the tragus to the mouth corner and from the outer canthus to the mouth corner, showed statistically significant differences ( P =0.012 and P =0.001, respectively). The anti-edema effect of hyaluronidase was more effective in the maxilla than in the mandible. In the maxilla, the percentage of facial swelling was significant for three measurements. However, in the mandible, the percentage of facial swelling was significant for only one measurement. Low levels of pain that were similar at T2 and T3 were reported in both groups. Conclusion The results indicate the degree of swelling was lower in the test group and hyaluronidase appeared to be more effective in the maxilla. The degree of pain reduction was similar between groups. Further in vivo and randomized controlled trials with larger sample sizes are warranted.

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Section: Discussionmentioning

confidence: 99%

Efficacy of local hyaluronidase administration in guided bone regeneration surgery: a randomized controlled trial

Kwoen

Choi

Kim

et al. 2021

JKAOMS

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“…In vivo and clinical studies have documented the consequent anti-edema effect of HUD 12 , 26 , 27 . By resolving ground substance of the connective tissue, HUD was shown to be effective in early treatment of hematoma and fibrosis 28 , 29 . Furthermore, HUD regulates inflammatory response by decreasing the infiltration of inflammatory mediators such as neutrophils to the inflammatory site 8 or increasing anti-inflammatory cytokines including TNFα (tumor necrosis factor alpha), interleukin (IL)-1α, IL-4, and IL-10, thus promoting wound healing 10 .…”

Section: Discussionmentioning

confidence: 99%

Efficacy of submucosal injection of hyaluronidase after mandibular third molar surgery: a randomized controlled trial

Lee

Kim

Nam

2022

JKAOMS

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Objectives: This study aimed to investigate the efficacy of postoperative submucosal injection of hyaluronidase (HUD) for reducing sequelae and quality of life (QOL) after mandibular third molar (M3M) surgery. Materials and Methods: Participants with bilateral impacted M3M underwent surgical extraction with a split-mouth randomized controlled study design. M3M were removed by the same surgeon in 2 sessions, one a control and the other experimental. Submucosal injection of HUD was performed in the experimental session and submucosal injection of saline in the control session. Mouth opening, facial swelling, and pain intensity were measured before surgery, and then 2 and 7 days after surgery. The QOL of participants following surgery was evaluated by means of a patient-centered outcome questionnaire (PCOQ). Results: A total of 36 patients was included in the final data analysis. There was a significant reduction in the maximal mouth opening and postoperative pain in the experimental side at the 2 and 7 days after surgery (P<0.05), and a remarkable difference in facial swelling was reported on the experimental side 7 days after surgery (P<0.05). The PCOQ demonstrated that participants reported less pain and swelling on the experimental side. Conclusion:The present study provides clinical evidence that submucosal administration of HUD immediately after M3M surgery reduced postoperative discomfort and improved patients' QOL.

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“…9 Isso acontece devido a uma resposta exagerada à cicatrização de feridas ou a um hematoma não reconhecido e não tratado? 3 Alguns autores defendem que os pacientes não se incomodam com os nódulos. 11 Essa não é nossa experiência.…”

Section: Discussionunclassified

“…Os pequenos são geralmente reabsorvidos espontaneamente 2 , mas, em alguns casos, podem induzir complicações. 2,3 A evolução do hematoma compreende três etapas: Estágio I (formação inicial): ferida inchada, quente e flutuante. Requer intervenção imediata.…”

Section: Introductionunclassified

Reconstrução perioral após cirurgia micrográfica de Mohs: análise de 108 casos

Trevisan¹,

Maya²,

Bittner³

et al. 2021

S&CD

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Hematoma em cirurgia dermatológica: dicas para evitar resultados inestéticos a partir da hialuronidase e drenagem de hematomasHematoma in aesthetic surgery: tips to avoid unaesthetic results Hyaluronidase and hematoma drainage RESU MO Hematomas são comuns após cirurgias cosméticas. Quando pequenos, são conduzidos de maneira conservadora, pois, na maioria das vezes, são reabsorvidos. No entanto, mesmo pequenas coleções, quando não ativamente abordadas, podem resultar em maus resultados estéticos. A drenagem precoce tem sido especialmente descrita em revistas de Otorrinolaringologia e Radiologia. As autoras apresentam uma abordagem para o tratamento precoce de hematomas. Ênfase especial é dada ao uso da hialuronidase, bem conhecida pelos dermatologistas e cirurgiões plásticos por sua capacidade de dissolver o ácido hialurônico, mas sua utilidade no tratamento de hematomas não é amplamente difundida entre esses especialistas.

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Treatment of post-traumatic hematoma and fibrosis using hyaluronidase injection

Cited by 8 publications

References 6 publications

Efficacy of local hyaluronidase administration in guided bone regeneration surgery: a randomized controlled trial

Efficacy of local hyaluronidase administration in guided bone regeneration surgery: a randomized controlled trial

Efficacy of submucosal injection of hyaluronidase after mandibular third molar surgery: a randomized controlled trial

Reconstrução perioral após cirurgia micrográfica de Mohs: análise de 108 casos

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