Treatment of Polycythaemia with Radioactive Phosphorus

Harman, John; Hart, P. L. d. V.; Ledlie, E.M.

doi:10.1136/bmj.1.4919.930

Cited by 13 publications

(4 citation statements)

References 2 publications

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“…Two patients had gout, in both for more than five years before polycythaemia was diagnosed. Haemorrhage was not so common as in other reported series (Harman et al, 1955), and was never serious. Cardiovascular disease, and in particular thrombotic phenomena, were common, however, half of the patients giving a history of one or more of the following: phlebothrombosis, pulmonary embolism, coronary thrombosis, angina pectoris, cerebral thrombosis, intermittent claudication, and gangrene.…”

mentioning

confidence: 38%

“…In the United Kingdom the largest reported series is that of Harman et al (1955), comprising 48 cases, two smaller groups of patients having previously been described by Bodley Scott (1953) and Abbatt et al (1954).…”

mentioning

confidence: 92%

“…This has not been done routinely in Leeds, but in 10 patients initial venesection was considered desirable to relieve symptoms. No attempt, however, was made to reduce the red-cell mass to normal by massive venesection as suggested by Harman et al (1955). Patients were treated as out-patients and usually seen at monthly intervals after the first injection.…”

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confidence: 99%

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Treatment of Polycythaemia Vera with Radioactive Phosphorus

Fountain¹

1957

BMJ

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confidence: 38%

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confidence: 92%

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Treatment of Polycythaemia Vera with Radioactive Phosphorus

Fountain¹

1957

BMJ

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“…The treatment of polycythaemia vera with radioactive phosphorus (32P) was introduced in 1938 by Lawrence (1940); combined with venesection, it proved to be both effective and free from side-effects and was accepted as the best form of treatment (Scott, 1953;Harman, Hart, and Ledlie, 1955). Aplastic anaemia was its greatest hazard, but usually followed its use in unsuitable cases or in excessive dosage (Calabresi and Meyer, 1959).…”

Section: Discussionmentioning

confidence: 99%

Treatment of polycythaemia vera.

Watkins¹,

Fairley²,

Scott³

1967

BMJ

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Age, per se, plays no direct part in determining rate of change of pressure in these populations even though, as is seen in Figs. 1 and 2, mean pressures are much higher in the old than in the young and even though almost all old people in these populations have high pressures. Age appears to play a part solely because the blood-pressure changes on average are positive and increase with higher pressures.'he relation between change of pressure and mean pressure also appears to be a graded phenomenon-the higher the pressure the greater the rate of increase-and seems partially to reconcile the conflicting views on the nature of unexplained hypertension.If this relation were found to be causal it could explain the observations that some individuals and some races show no apparent increase in pressure with age. For example, the populations in Oceania studied by Maddocks (1961) and Lovell (1963), where old people have the same pressures as young adults, have mean pressures below the levels at which our data suggest that a self-perpetuating mechanism could be implicated. But our analysis has shown only an association between change of pressure and mean pressure, not a causal relationship. It is possible that minor but sustained increases of pressure, due to a variety of environmental and genetic influences, could lead to changes in function and structure which perpetuate a vicious circle, but some other factor acting in a similar fashion may underlie the relationship found.A controlled therapeutic trial might show whether the pressure attained determines the subsequent increments in pressure; if, for example, it could be shown that after a reduction in pressure effected by hypotensive drugs the subsequent changes in pressure of previously hypertensive subjects revert to those occurring spontaneously in subjects with lower pressures, this would be strong evidence for a causal relationship. SummaryData obtained from the longitudinal surveys of arterial blood pressure in two general population samples have been used to examine the relation between change of blood pressure, the mean pressure attained, and age.It has been shown, by multiple regression analysis of change of pressure on mean pressure and age, that in these populations changes in pressure during intervals of 10 and 8O years are highly significantly related to mean pressures, but only indirectly related to age. This implies that ageing plays no direct part in determining the rate of change of pressure; age appears to play a part solely because the blood-pressure changes are positive and increase with higher pressures.If change of pressure is determined.by attained pressure, this would explain the observation that some individuals and some races show no apparent increase of pressure with age, and would partially reconcile the conflicting views on the nature of unexplained hypertension. However, the evidence has shown only association, not causality.We wish to record our thanks to the people of the Rhondda Fach and Vale of Glamorgan who so willingly continue to c...

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Die Therapie der Polycythaemia rubra vera Vaquez-Osler

Ruckensteiner¹

1970

Spezielle Strahlentherapie Gutartiger Erkrankungen

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Treatment of Polycythaemia with Radioactive Phosphorus

Cited by 13 publications

References 2 publications

Treatment of Polycythaemia Vera with Radioactive Phosphorus

Treatment of Polycythaemia Vera with Radioactive Phosphorus

Treatment of polycythaemia vera.

Die Therapie der Polycythaemia rubra vera Vaquez-Osler

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