Treatment of Plantar Warts in ChOdren with a Salicylic Acid‐Podophyllin‐Cantharidin Product

Coskey, Ralph J.

doi:10.1111/j.1525-1470.1984.tb00446.x

Cited by 33 publications

(26 citation statements)

References 7 publications

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“…33 Cellulitis developed in 4 patients whose plantar warts were initially treated with a mixture of 1% cantharidin, salicylic acid, and podophyllin that was left on for 24 hours, and then the warts were debrided with silver nitrate. 26 In a retrospective study of 300 children with molluscum contagiosum treated with cantharidin, 90% of the patients experienced resolution of symptoms and an additional 8% noted some improvement. 30 The authors used 52.5 mg of cantharidin crystals mixed in 7.5-mL flexible collodion.…”

Section: Dermatological Uses Of Cantharidinmentioning

confidence: 99%

“…Cantharidin should be applied only in the office by a physician 26 or under the direct supervision of a physician. Although 1 report advocates home use of cantharidin for warts, we believe that home use should be strictly avoided, 28 because severe blistering can result from improper use, 24 and because ingestion, especially by children, can be fatal.…”

Section: Dermatological Uses Of Cantharidinmentioning

confidence: 99%

“…16,17,[23][24][25][26] Proprietary formulations consisting of 0.7% cantharidin in a film-forming vehicle containing acetone, ether, and alcohol can be purchased from several companies (eg, Dormer Laboratories, Rexdale, Ontario; Omniderm, Hudson, Quebec; PharmaScience, Montreal, Quebec; College Pharmacy, Colorado Springs, Colo; Belle Haven Pharmacy, Alexandria, Va; and Dermatologic Lab and Supply, Council Bluffs, Iowa). Alternatively, compounding 0.7% or 0.9% cantharidin solution with equal parts of acetone and flexible collodion may be done.…”

Section: Dermatological Uses Of Cantharidinmentioning

confidence: 99%

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Cantharidin Revisited

Moed

Shwayder²,

Chang³

2001

Arch Dermatol

175

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antharidin, a vesicant produced by beetles in the order Coleoptera, has a long history in both folk and traditional medicine. In dermatology, topical cantharidin has long been used to treat warts and molluscum. In 1962, cantharidin lost Food and Drug Administration (FDA) approval owing to the failure of its manufacturers to submit data attesting to cantharidin's efficacy. However, it is expected that the FDA will soon include cantharidin on its "Bulk Substances List," which would permit physicians or pharmacists to compound cantharidin to be used in the office for individual patients. A comprehensive discussion of the origins, folk uses, current FDA status, current dermatologic uses, and effects of cantharidin poisoning has been compiled herein. No cases of systemic intoxication or scarring have been reported with the proper use of cantharidin by a physician. Cantharidin is a safe and valuable medication and should be readded to the dermatologic therapeutic armamentarium.

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Section: Dermatological Uses Of Cantharidinmentioning

confidence: 99%

Section: Dermatological Uses Of Cantharidinmentioning

confidence: 99%

Section: Dermatological Uses Of Cantharidinmentioning

confidence: 99%

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Cantharidin Revisited

Moed

Shwayder²,

Chang³

2001

Arch Dermatol

175

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“…A hyperkeratotic wart should first be pared with a #15 scalpel blade, then destroyed with high-concentration salicylic acid (17 % liquid or 40 % plaster), cryotherapy with liquid nitrogen, or electrodesiccation with curettage [82][83][84][85][86][87][88]. A 2011 metaanalysis of pooled randomized controlled trials suggested that salicylic acid should be used as the first-line agent, and a combination of salicylic acid with aggressive cryotherapy as second-line treatment [89].…”

Section: Warts (Verrucae)mentioning

confidence: 99%

Skin Conditions of Baseball, Cricket, and Softball Players

et al. 2013

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Each year in the United States over 80 million people participate in bat-and-ball sports, for example baseball and softball. Cricket, the world's second most popular sport, is enjoyed by hundreds of millions of participants in such countries as India, Pakistan, Australia, New Zealand, Bangladesh, South Africa, West Indies, Sri Lanka, United Kingdom, and Zimbabwe. Although any player can develop skin disease as a result of participation in these bat-and-ball sports, competitive team athletes are especially prone to skin problems related to infection, trauma, allergy, solar exposure, and other causes. These diseases can produce symptoms that hinder individual athletic performance and participation. In this review, we discuss the diagnosis and best-practice management of skin diseases that can develop as a result of participation in baseball, softball, and cricket.

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“…Salicylic acid-podophyllin-cantharidin combinations can be helpful for treating warts in children (81% effectiveness in one study). 8 Duct tape may have a role in treating VV. A study noted that of 51 patients, 26 (51%) were treated with duct tape and 25 (49%) were treated with cryotherapy; 22 patients (85%) in the duct tape arm vs. 15 (60%) in the cryotherapy arm had complete resolution of their VV; however, this has not been the case for me.…”

mentioning

confidence: 99%

Treatment of Verruca Vulgaris

Scheinfeld

2006

Skinmed

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A 14-year-old boy presented with a 5-mm wart on his ankle (Figure). His mother was given the option of various destructive measures. She chose cryosurgery. Liquid nitrogen was applied to the area with a Brymill Mini-Cryogun (Brymill Cryogenic Systems, Ellington, CT) in three 10-second bursts, with intervals of total tissue thawing. One month later, there was only residual mild macular erythema, but no wart was present in the area where the wart had been.No treatment eradicates all warts in all cases, and 20%-40% of verruca vulgaris (VV) will disappear over 1-2 years without treatment. Since VV causes morbidity and can spread, treatment is medically necessary. Treatment does not prevent wart dissemination, because the papilloma virus remains in the skin. 1 As straightforward as the use of liquid nitrogen could be, controversy exists surrounding its optimal use. For example, a 10-second cryogun application of liquid nitrogen to VV is more effective than shorter applications. 2 According to one study, cryogen gun and cotton tip with liquid nitrogen are equally effective. 3 The use of a double freeze-thaw cycle confers little or no advantage over a single freeze in hand VV treatment, but may be useful in plantar VV treatment. 4 Two freeze-thaw cycles and paring before freezing in one study improved the cure rate for plantar warts but not hand VV. 5,6 The optimal therapeutic interval between VV treatments is unclear, although one study noted that cure relates to the number of treatments rather than the frequency of treatments.Salicylic acid is an initial therapy for flat warts on the face, plantar warts, and flat and common warts on the hands. An evidencebased study 7 identified topical therapy with salicylic acid as safe and effective and reports that no clear evidence exists to prove that other therapies have an advantage in regard to higher cure rates or fewer adverse effects. Also noted was that six randomized clinical trials demonstrated a cure rate of 75% in those treated with salicylic acid compared with 48% in the control group. Salicylic acid-podophyllin-cantharidin combinations can be helpful for treating warts in children (81% effectiveness in one study). 8 Duct tape may have a role in treating VV. A study noted that of 51 patients, 26 (51%) were treated with duct tape and 25 (49%) were treated with cryotherapy; 22 patients (85%) in the duct tape arm vs. 15 (60%) in the cryotherapy arm had complete resolution of their VV; however, this has not been the case for me. 9 Electrodesiccation, pulse dye laser, and photodynamic therapy can treat VV, but they have not been shown to be more effective than cryotherapy.Several studies using imiquimod, which is only indicated for the condyloma, note high cure rates when applied twice daily for 2-12 months or once a day and occluded for 4 weeks. I have never found imiquimod useful in treating VV. Using a bifurcated needle, bleomycin sulfate (1 mg/mL sterile saline solution) can be introduced into warts with excellent effectiveness, but with many possible side effects. Or...

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Treatment of Plantar Warts in ChOdren with a Salicylic Acid‐Podophyllin‐Cantharidin Product

Abstract: One hundred and twenty-one children with plantar warts were treated with a topical preparation containing salicylic acid, 30%; podophyllin, 5%; and cantharidin, 1%. One hundred patients or their families were reached 6 months to 1 year later. This treatment was effective in 81 cases.

Cited by 33 publications

References 7 publications

Cantharidin Revisited

Cantharidin Revisited

Skin Conditions of Baseball, Cricket, and Softball Players

Treatment of Verruca Vulgaris

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