Treatment of plague: promising alternatives to antibiotics

Anisimov, Andrey P.; Amoako, Kingsley K.

doi:10.1099/jmm.0.46697-0

Cited by 79 publications

(70 citation statements)

References 142 publications

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“…The Y. pestis MDR plasmid pIP1202, however, was isolated from a patient with bubonic plague (16). Since antimicrobial therapy in this case was very short and antimicrobial resistance phenotypes have otherwise very rarely been found in Y. pestis (1,15), resistance determinants on pIP1202 were probably acquired prior to the infection of the human host with Y. pestis IP275. Interestingly, sulfonamides and tetracyclines were among the first antimicrobial compounds used in human and animal medicine (12,13).…”

Section: Discussionmentioning

confidence: 99%

“…This might indicate that components involved in core plasmid functions are subject to recombination even between unrelated plasmids. The isolation of Y. pestis strain IP275 with resistance to most antimicrobial drugs recommended for acute or preventive treatment of plague has caused considerable concern in the public health community, not the least due to potential biodefense concerns (1,15). In this context, it is revealing that the 100-kb plasmid backbones of pIP1202, which was isolated in Madagascar in 1995, and pP99-018, which was isolated in Japan in 1999, lack any SNPs and that the core plasmids of pIP1202 and pP91278, isolated in the United States in 1991, differ by only two SNPs.…”

Section: Discussionmentioning

confidence: 99%

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Comparative Genomics of the IncA/C Multidrug Resistance Plasmid Family

et al. 2009

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Multidrug resistance (MDR) plasmids belonging to the IncA/C plasmid family are widely distributed among Salmonella and other enterobacterial isolates from agricultural sources and have, at least once, also been identified in a drug-resistant Yersinia pestis isolate (IP275) from Madagascar. Here, we present the complete plasmid sequences of the IncA/C reference plasmid pRA1 (143,963 bp), isolated in 1971 from the fish pathogen Aeromonas hydrophila, and of the cryptic IncA/C plasmid pRAx (49,763 bp), isolated from Escherichia coli transconjugant D7-3, which was obtained through pRA1 transfer in 1980. Using comparative sequence analysis of pRA1 and pRAx with recent members of the IncA/C plasmid family, we show that both plasmids provide novel insights into the evolution of the IncA/C MDR plasmid family and the minimal machinery necessary for stable IncA/C plasmid maintenance. Our results indicate that recent members of the IncA/C plasmid family evolved from a common ancestor, similar in composition to pRA1, through stepwise integration of horizontally acquired resistance gene arrays into a conserved plasmid backbone. Phylogenetic comparisons predict type IV secretion-like conjugative transfer operons encoded on the shared plasmid backbones to be closely related to a group of integrating conjugative elements, which use conjugative transfer for horizontal propagation but stably integrate into the host chromosome during vegetative growth. A hipAB toxin-antitoxin gene cluster found on pRA1, which in Escherichia coli is involved in the formation of persister cell subpopulations, suggests persistence as an early broad-spectrum antimicrobial resistance mechanism in the evolution of IncA/C resistance plasmids.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparative Genomics of the IncA/C Multidrug Resistance Plasmid Family

et al. 2009

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“…In all cases, PY100 formed large plaques at 37°C on the bacterial lawns and may be of interest for treating infections with these pathogens. Especially, since Y. pestis is classified as a potential biowarfare or bioterror agent, phage therapy may be considered as an approach to counter such a threat (4,17). We report here on the host range, burst size, genome sequence, proteomic characteristics, and packaging mechanism of this phage.…”

mentioning

confidence: 99%

“…Reports on phage therapy experiments with yersiniophages are rare in the literature; however, one remarkable historic report is from the experiments of d'Herelle, who reported the successful treatment of four plague patients with lytic phages (13,4). The renewed interest in phage therapy experiments due to the increase in antibiotic resistance of several pathogenic bacteria prompted us to search for Yersinia phages that lyse their hosts at 37°C.…”

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confidence: 99%

Broad-Host-Range Yersinia Phage PY100: Genome Sequence, Proteome Analysis of Virions, and DNA Packaging Strategy

et al. 2008

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PY100 is a lytic bacteriophage with a broad host range within the genus Yersinia. The phage forms plaques on strains of the three human pathogenic species Yersinia enterocolitica, Y. pseudotuberculosis, and Y. pestis at 37°C. PY100 was isolated from farm manure and intended to be used in phage therapy trials. PY100 has an icosahedral capsid containing double-stranded DNA and a contractile tail. The genome consists of 50,291 bp and is predicted to contain 93 open reading frames (ORFs). PY100 gene products were found to be homologous to the capsid proteins and proteins involved in DNA metabolism of the enterobacterial phage T1; PY100 tail proteins possess homologies to putative tail proteins of phage Aa⌽23 of Actinobacillus actinomycetemcomitans. In a proteome analysis of virion particles, 15 proteins of the head and tail structures were identified by mass spectrometry. The putative gene product of ORF2 of PY100 shows significant homology to the gene 3 product (small terminase subunit) of Salmonella phage P22 that is involved in packaging of the concatemeric phage DNA. The packaging mechanism of PY100 was analyzed by hybridization and sequence analysis of DNA isolated from virion particles. Newly replicated PY100 DNA is cut initially at a pac recognition site, which is located in the coding region of ORF2.

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“…Since Y. pestis is classified as a potential biowarfare or bioterror agent, phage therapy may be considered as an approach to counter such a threat (46,47). A major concern regarding the use of phages in the treatment of infectious diseases still remains the emergence of phage-resistant mutants (23).…”

Section: Discussionmentioning

confidence: 99%

Outer Membrane Proteins Ail and OmpF of Yersinia pestis Are Involved in the Adsorption of T7-Related Bacteriophage Yep-phi

Zhao

Cui

Yan

et al. 2013

J Virol

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Yep-phi is a T7-related bacteriophage specific to Yersinia pestis, and it is routinely used in the identification of Y. pestis in China. Yep-phi infects Y. pestis grown at both 20°C and 37°C. It is inactive in other Yersinia species irrespective of the growth temperature. Based on phage adsorption, phage plaque formation, affinity chromatography, and Western blot assays, the outer membrane proteins of Y. pestis Ail and OmpF were identified to be involved, in addition to the rough lipopolysaccharide, in the adsorption of Yep-phi. The phage tail fiber protein specifically interacts with Ail and OmpF proteins, and residues 518N, 519N, and 523S of the phage tail fiber protein are essential for the interaction with OmpF, whereas residues 518N, 519N, 522C, and 523S are essential for the interaction with Ail. This is the first report to demonstrate that membrane-bound proteins are involved in the adsorption of a T7-related bacteriophage. The observations highlight the importance of the tail fiber protein in the evolution and function of various complex phage systems and provide insights into phage-bacterium interactions.

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Treatment of plague: promising alternatives to antibiotics

Cited by 79 publications

References 142 publications

Comparative Genomics of the IncA/C Multidrug Resistance Plasmid Family

Comparative Genomics of the IncA/C Multidrug Resistance Plasmid Family

Broad-Host-Range Yersinia Phage PY100: Genome Sequence, Proteome Analysis of Virions, and DNA Packaging Strategy

Outer Membrane Proteins Ail and OmpF of Yersinia pestis Are Involved in the Adsorption of T7-Related Bacteriophage Yep-phi

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