Treatment of photodamaged facial skin with topical tretinoin

Leyden, James J.; Grove, Gary L.; Grove, Mary Jo; Thorne, E. George; Lufrano, Laura

doi:10.1016/s0190-9622(89)70231-0

Cited by 147 publications

(61 citation statements)

References 3 publications

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“…Such an unexpected change in the protocol was unavoidable ; we have not had any experience of the effects of topical tretinoin properties in the Japanese because it is not unavailable in this country. A favorable effect of tretinoin on skin roughness has been reported (Leyden 1989) ; skin roughness improved more prominently in the topical application of tretinoin compared with that in the treatment with petrolatum alone (Leyden 1989). We confirmed that in almost all the individuals including one patient with xeroderma pigmentosum who tolerated the initial irritation the skin texture dramatically improved after repeated applications of tretinoin.…”

Section: Discussionsupporting

confidence: 81%

The Effect of Topical Tretinoin on the Photodamaged Skin of the Japanese.

Tadaki

Watanabe

Kumasaka

et al. 1993

Tohoku J. Exp. Med.

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Section: Discussionsupporting

confidence: 81%

The Effect of Topical Tretinoin on the Photodamaged Skin of the Japanese.

Tadaki

Watanabe

Kumasaka

et al. 1993

Tohoku J. Exp. Med.

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“…Benefits of the 0.1 % t-RA treatment included aesthetic improvement in surface texture, skin color, laxity, wrinkling, and mottled hyperpigmentation. These results provide further support for the t-RA-induced improvement of photoaged skin of human beings (1, 4, 5, 9, 14,17,20,21) and are consistent with data reported in hairless mice (2, 3, 11).…”

Section: Drscussro~supporting

confidence: 91%

Effects of All-frans-Retinoic Acid on the Dorsal Skin of: Hairless Dogs

Kimura

Doi

1998

Toxicol Pathol

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Daily topical treatment with all-trans-retinoic acid (t-RA; 0.1% t-RA solution or 0.05% t-RA cream) was compared with its vehicle with regard to improvement of intrinsically aged skin of hairless descendants of Mexican hairless dogs. After 1 mo of treatment with 0. I% t-RA solution, improvements were noted in skin texture, wrinkling, and pigmentation. Treatment with 0.05% t-RA cream caused an intense adverse effect, retinoid dermatitis. Histologically, 0.1% t-RA solution induced restoration of the skin structure of hairless dogs, resulting in an apparcnt increase in compaction of the stratum comeum and the epidermal thickness. The epidermis became hyperplastic with definite development of the stratum granulosum. The border between the epidermis and dermis became wavy, and dermal papillae were reconstituted. The 0.1% t-RA solution caused a remarkable decrease in melanin granules. In the dermis, the number of small vessels increased and vasodilation was seen. In sites treated with 0.05% t-RA cream, the stratum comeum became involved in dyskeratotic changes. There was a significantly greater increase in epidermal and granular layer thickness. Necrotic and edematous changes were found in the epidermis, and severe inflammatory reactions were also observed in the dermis. In the t-RAuntreated sites, the structure of the aged skin remained histologically unimproved during the study. The results suggest that hairless dogs are useful laboratory animals for evaluating the effectiveness and side effects of t-RA agents.

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“…Sequential clinical analysis and patient questionnaires were performed at baseline, 2 weeks, 1 month, 2 months, and 3 months. In addition, optical profilometry measurements of silicone rubber casts [31][32][33] were taken from identical sites at the lateral canthal (crow's feet) areas. Standard photographs were taken at baseline and at the end of the study (3 months).…”

Section: Methodsmentioning

confidence: 99%

Use of Topical Ascorbic Acid and Its Effects on Photodamaged Skin Topography

Traikovich

1999

Arch Otolaryngol Head Neck Surg

142

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Objective: To determine the efficacy of topical ascorbic acid application in treating mild to moderate photodamage of facial skin using an objective, computerassisted image analysis of skin surface topography and subjective clinical, photographic, and patient selfappraisal questionnaires.Design: A 3-month, randomized, double-blind, vehiclecontrolled study.Setting: Facial plastic surgery private practice.Patients: Nineteen evaluable volunteer sample patients aged between 36 and 72 years with Fitzpatrick skin types I, II, and III who were in good physical and mental health with mild to moderately photodamaged facial skin were considered for analysis.Intervention: Coded, unmarked medications were randomly assigned to the left and right sides of each subject's face, one containing the active agent, topical ascorbic acid (Cellex-C high-potency serum; Cellex-C International, Toronto, Ontario), the other, the vehicle serum (Cellex-C International). Three drops (0.5 mL) of each formulation were applied daily to the randomly assigned hemifaces over the 3-month study period. Treatment assignments were not disclosed to subjects, clinicians, or personnel involved in analyzing skin replicas. Main Outcome Measures:Specific clinical parameters were evaluated and graded on a 0-to 9-point scale (0, none; 1-3, mild; 4-6, moderate; and 7-9, severe). Reference photographs were used to standardize grading criteria. Overall investigator scores were compared with baseline and graded as excellent (much improved), good (improved), fair (slightly improved), no change, or worse. Patient self-appraisal questionnaires rated the degree of improvement (much improved, improved, slightly improved, no change, or worse) and reported adverse effects (burning, stinging, redness, peeling, dryness, discoloration, itching, and rash). Standard photographs were taken at baseline, including anteroposterior and left and right oblique views to facilitate subsequent clinical evaluations, and at the end of therapy for comparison. Optical profilometry analysis was performed on the skin surface replicas of the lateral canthal (crow's feet) region, comparing baseline to end-of-study specimens. Using this computer-based system, the resulting image was digitally analyzed, and numeric values were assigned to reflect surface features. The parameters obtained included R z , R a , and shadows. These values provided objective data that document pretreatment and posttreatment texture changes proportional to the degree of wrinkling, roughness, and other surface irregularities.Results: Optical profilometry image analysis demonstrated a statistically significant 73.7% improvement in the R a and shadows north-south facial axis values with active treatment greater than vehicle control, as well as a trend for improvement in the R z north-south facial axis parameter, showing a 68.4% greater improvement of active treatment vs vehicle control. Clinical assessment demonstrated significant improvement with active treatment greater than control for fine wrinkling, tactile roughnes...

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Treatment of photodamaged facial skin with topical tretinoin

Cited by 147 publications

References 3 publications

The Effect of Topical Tretinoin on the Photodamaged Skin of the Japanese.

The Effect of Topical Tretinoin on the Photodamaged Skin of the Japanese.

Effects of All-frans-Retinoic Acid on the Dorsal Skin of: Hairless Dogs

Use of Topical Ascorbic Acid and Its Effects on Photodamaged Skin Topography

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