Treatment of Peyronie's Disease by Extracorporeal Shockwave Therapy: Evaluation of Our Preliminary Results

Abstract

Our preliminary results with a response rate of 59% with ESWT for Peyronie's disease, including a 17% complete remission rate, is encouraging. However, further multicenter studies will have to prove if ESWT is a real therapeutic option for this disease.

Objective and Subjective Changes in Patients with Peyronie's Disease after Management with Shockwave Therapy

“…[8][9][10][11][13][14][15][16] Accordingly, statements from these studies concerning the treatment outcome of patients with Peyronie's disease are restricted. We carefully selected our candidates, although the majority of patients were reluctant to participate in a study with a sham treatment group.…”

Peyronie's disease: a critical appraisal of current diagnosis and treatment

“…In a second study, a case series of 24 patients undergoing plaque lithotripsy, who had previously failed medical management, demonstrated a significant decrease in penile angulation in 17%. 84 The treatment was Peyronie's disease: diagnosis and treatment JF Smith et al associated with significant discomfort and required local anesthesia. A series of 40 patients with early stage PD demonstrated some benefit with this approach.…”

A Critical assessment of extracorporeal shock-wave therapy for Peyronie’s disease

“…Based on the various trial designs developed for ESWT, the absence of a standard protocol regarding patient selection, modalities of shock-wave application, and pre-and post-treatment patient evaluation contributes to making this kind of treatment for Peyronie's disease investigational and not actually fully applicable in everyday clinical practice. 24,25], only patients who had previously failed to respond to oral drug therapy received ESWT, leading to a selection of patients with more severe penile deformities and with a more stable disease. In contrast, a prospective study by Lebret et al [15] was designed to assess the results obtained by ESWT only in patients with recently developed (ie, less than 6 mo) palpable penile plaques.…”

“…In addition, the increase in the energy applied to the plaque seems to be associated with a more favorable outcome after treatment [16]. Other series reported similar percentages of response after ESWT [22,25].…”

“…Severe pain requiring local penile block has been reported [14•]. Local penile anesthesia before therapy has also been described [25]. Urethral bleeding has been reported in 1% [19,21•], 5.7% [5], 7%…”