Treatment of persistent congenital chylothoraxwith intrapleural injection of sapylin in infants

Hua, Qingwang; Lin, Zhiyong; Hu, Xiuying; Zhao, Qifeng

doi:10.12669/pjms.325.10142

Cited by 4 publications

(7 citation statements)

References 10 publications

(8 reference statements)

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“…[49], [51-52], [54-58], [60-64], [66], [70][71][72][73][74][75][76][77][78][79][80][81], [84][85][86][87][88], [90][91][92][93], [95][96][97][98][99][100][101][102][103].…”

Section: Resultsmentioning

confidence: 99%

“…[55], [64], [64], [66], [71], [73], [74], [78], [90]- [93]. TPN allows for a faster reduction in pleural effusion [83].…”

Section: Resultsmentioning

confidence: 99%

“…Less common methods of nutritional treatment include low-fat diet (2.6 % patients [32], [38], [44], [49], [54], [57], [61], [92], [95], [96]), completely fat-free diet (5,8 % [13], [14], [20], [46], [51], [73], [75], [76], [97], [98]) or in infants -milk with modified fat content (7,5 % [3], [23], [84]). At the same time, authors of many publications do not provide specific diet modifications (10,9 %) [22], [26], [29], [31], [42], [60], [66], [70], [73], [80], [86], [99], [100].…”

Section: Resultsmentioning

confidence: 99%

“…Treatment with somatostatin or octreotide has been implemented in more than half of the patients from the reviewed literature, in addition to dietary modifications (56,3%) and it achieved a desired therapeutic effect in 63.2 % of them. [2-3], [11][12], [17], [19][20], [25]- [28], [31]- [33], [37], [39], [41]- [43], [45], [52], [54]-[57], [62]- [64], [66], [70][71], [73], [77]- [80], [84], [86][87], [91][92], [95][96], [98], [103] Due to certain differences in pharmacokinetic properties and route of administration, octreotide is a more popular choice (79,9 % of patients) than somatostatin (10,4 %) [3], [11][12], [17], [19][20], [25]- [27], [31][32][33], [37], [39], [41]- [43], [45], [52],...…”

Section: Resultsmentioning

confidence: 99%

“…Sildenafil, which is a phosphodiesterase type 5 (PDE5) inhibitor, increases the concentration of cGMP in the cells of the smooth muscles of the pulmonary vessels, leading to pulmonary vasodilation, which prevents the development of pulmonary hypertension [17], [26], [55]. In the event of chyle infection in the pleural cavity, antibiotic therapy is initiated [17], [41], [66], [75]. Intravenous steroids are also frequently administered in order to reduce inflammation [19], [25], [32], [62], [72], [79], [80], [84], [87], [103].…”

Section: Resultsmentioning

confidence: 99%

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Etiological factors and treatment of chylothorax in paediatric patients - a systematic review

Knop

Kochanowska

Piasecka

et al. 2022

J Educ Health Sport

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Chylothorax is an accumulation of chyle in the pleural cavity. It is a relatively rare cause of pleural effusion in children and its annual incidence is 14 cases per 100 000 children in Europe. The pleural fluid triglyceride level greater than 110 mg/dl with a cholesterol level lower than 200 mg/dl confirms the diagnosis of chylothorax. Medical imaging are also necessary such as a non-invasive and easily accessible lung ultrasound. Symptoms of this disease are tachypnea, dyspnea, and in some cases dry cough. This review aims to summarize the current literature regarding chylothorax in children, analyze its possible etiologies and treatments. The causes of chylothorax are varied. It may appear after surgical interventions, traumas, infections and also be congenital. Iatrogenic factors are the most common cause of chylothorax in children with cardiothoracic surgeries. Management of chylothorax can be quite complex and highly variable, depending on patient’s condition and their response to the introduced treatment. Conservative treatment consisting of nutrition therapy, chest drain, and pharmacotherapy is typically a first-line of treatment. Diet modification consist in dietary supplements enriched with medium chain triglycerides (MCT) or starting the patient on a total parenteral nutrition (TPN). In most of the analyzed cases the conservative treatment alone proved sufficient in the management of chylothorax. In case of its failure, surgical treatment was a secondary therapy choice. One of the most common surgical procedures for pleural effusion is a thoracic duct ligation (TDL) or pleurodesis and both of these methods are highly effective therapy for chylothorax. This review of the literature reveals a wide variety of causes and methods of treatment of chylothorax. There are no clear standards of management and the therapy is adjusted to the clinical condition of the patient.

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“…[49], [51-52], [54-58], [60-64], [66], [70][71][72][73][74][75][76][77][78][79][80][81], [84][85][86][87][88], [90][91][92][93], [95][96][97][98][99][100][101][102][103].…”

Section: Resultsmentioning

confidence: 99%